Ischemic cell death during a myocardial infarction leads to a multiphase reparative response
in which the damaged tissue is replaced with a fibrotic scar produced by fibroblasts and …

Fibroblasts comprise the largest cell population in the myocardium. In heart disease, the
number of fibroblasts is increased either by replication of the resident myocardial fibroblasts …

Abstract cGMP controls many cellular functions ranging from growth, viability, and
differentiation to contractility, secretion, and ion transport. The mammalian genome encodes …

Cardiac fibroblasts are the most prevalent cell type in the heart and play a key role in
regulating normal myocardial function and in the adverse myocardial remodeling that occurs …

Cardiac fibrosis plays a key role in the progression of diabetic cardiomyopathy (DCM).
Previous studies demonstrated the cardioprotective effects of natriuretic peptides. However …

It is now becoming apparent that dynamic changes occur within the interstitium that directly
contribute to adverse myocardial remodeling following myocardial infarction (MI), with …

Natriuretic peptides are a family of structurally related but genetically distinct
hormones/paracrine factors that regulate blood volume, blood pressure, ventricular …

Brain natriuretic peptide (BNP) is a 32 amino acid cardiac natriuretic peptide hormone
originally isolated from porcine brain tissue. The human BNP gene is located on …

Hypertension and heart failure (HF) are common diseases that, despite advances in medical
therapy, continue to be associated with high morbidity and mortality. Therefore, innovative …

Cardiac biomarkers are integral to the diagnosis and the treatment of acutely ill cardiac
patients. The Working Group on Acute Cardiac Care of the European Society of Cardiology …