New advances in pharmacoresistant epilepsy towards precise management-from prognosis to treatments

C Xu, Y Gong, Y Wang, Z Chen - Pharmacology & Therapeutics, 2022 - Elsevier
Epilepsy, one of the most severe neurological diseases, is characterized by abrupt recurrent
seizures. Despite great progress in the development of antiseizure drugs (ASDs) based on …

Eeg markers of treatment resistance in idiopathic generalized epilepsy: From standard eeg findings to advanced signal analysis

E Cerulli Irelli, G Leodori, A Morano, C Di Bonaventura - Biomedicines, 2022 - mdpi.com
Idiopathic generalized epilepsy (IGE) represents a common form of epilepsy in both adult
and pediatric epilepsy units. Although IGE has been long considered a relatively benign …

Clinical and EEG factors associated with antiseizure medication resistance in idiopathic generalized epilepsy

BK Kamitaki, M Janmohamed, P Kandula, C Elder… - …, 2022 - Wiley Online Library
Objective We sought to determine which combination of clinical and
electroencephalography (EEG) characteristics differentiate between an antiseizure …

Generalized fast discharges along the genetic generalized epilepsy spectrum: clinical and prognostic significance

E Cerulli Irelli, FA Barone, L Mari, A Morano… - Frontiers in …, 2022 - frontiersin.org
Objective To investigate the electroclinical characteristics and the prognostic impact of
generalized fast discharges in a large cohort of genetic generalized epilepsy (GGE) patients …

Drug-resistant epilepsy at the age extremes: Disentangling the underlying etiology

E Bartolini, AR Ferrari, S Lattanzi, S Pradella… - Epilepsy & Behavior, 2022 - Elsevier
The incidence of epilepsy is highest at the extreme age ranges: childhood and elderly age.
The most common syndromes in these demographics–self-limited epilepsies of childhood …

[HTML][HTML] Idiopathic (genetic) generalized epilepsy

M McWilliam, Y Al Khalili - 2019 - europepmc.org
Objectives:< p> Review the latest International League Against Epilepsy classification
system for epilepsy.</p>< p> Summarize the typical presentation of childhood absence …

Drug-resistant juvenile myoclonic epilepsy: A literature review

A Nica - Revue Neurologique, 2024 - Elsevier
Abstract The ILAE's Task Force on Nosology and Definitions revised in 2022 its definition of
juvenile myoclonic epilepsy (JME), the most common idiopathic generalized epilepsy …

EEG in focal and generalized epilepsies: Pearls and perils

MA Montenegro, K Valente - Epilepsy & Behavior, 2024 - Elsevier
Correctly diagnosing and classifying seizures and epilepsies is vital to ensure a tailored
approach to patients with epilepsy. The ILAE seizure classification consists of two main …

[HTML][HTML] Association of symptoms of psychiatric disease and electroencephalographic patterns in idiopathic generalized epilepsy

S Mangaard, J Gesche, T Krøigård, CP Beier - Epilepsy & Behavior, 2023 - Elsevier
Objective Idiopathic generalized epilepsies (IGE) are genetic epilepsies with alterations of
thalamo-frontocortical circuits that play a major role in seizure generation and propagation …

Predicting Pharmacoresistance in Drug-Naïve Temporal Lobe Epilepsy Using Ictal EEGs

Z Chen, Y Gong, C Xu, Z Zhang, S Zhang, X Li, X Qiu… - papers.ssrn.com
Background: One-third of patients with epilepsy are resistant to pharmacological
interventions. Early prediction of pharmacoresistance is therapeutically significant to …