A veritable explosion of primary research papers within the past 10 years focuses on
nucleolar and ribosomal stress, and for good reason: with ribosome biosynthesis …

The identification as cooperating targets of Proviral Integrations of Moloney virus in murine
lymphomas suggested early on that PIM serine/threonine kinases play an important role in …

The target of rapamycin (TOR) is a highly conserved protein kinase and a central controller
of growth. Mammalian TOR complex 2 (mTORC2) regulates AGC kinase family members …

The prevalence of patients with myelodysplastic syndromes (MDS) is increasing owing to an
ageing population and increased awareness of these diseases. MDS represent many …

Defects in ribosome biogenesis are associated with a group of diseases called the
ribosomopathies, of which Diamond-Blackfan anemia (DBA) is the most studied. Ribosomes …

Diamond-Blackfan anemia (DBA) is an inherited bone marrow failure syndrome
characterized by anemia, congenital abnormalities, and cancer predisposition. Small …

The gene encoding the ribosomal protein S19 (RPS19) is frequently mutated in Diamond-
Blackfan anemia (DBA), a congenital erythroblastopenia. The consequence of these …

Ribosomes are vital for cell growth and survival. Until recently, it was believed that mutations
in ribosomes or ribosome biogenesis factors would be lethal, due to the essential nature of …

Gene products mutated in the inherited bone marrow failure syndromes dyskeratosis
congenita (DC), cartilage-hair hypoplasia (CHH), Diamond-Blackfan anemia (DBA), and …

Diamond-Blackfan anemia (DBA) is a rare congenital disease affecting erythroid precursor
differentiation. DBA is emerging as a paradigm for a new class of pathologies potentially …