5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …

The efficacy of Roux-en-Y gastric-bypass (RYGB) and other bariatric surgeries in the
management of obesity and type 2 diabetes mellitus and novel developments in …

Serotonin communication operates mainly in the extracellular space and cerebrospinal fluid
(CSF), using volume transmission with serotonin moving from source to target cells (neurons …

Ghrelin is a multifaceted regulator of metabolism. Ghrelin regulates energy balance in the
short term via induction of appetite and in the long term via increased body weight and …

Abstract The 5-HT 2C receptor (R) displays a widespread distribution in the CNS and is
involved in the action of 5-HT in all brain areas. Knowledge of its functional role in the CNS …

The constitutive activity of different serotonin receptors (5-HTRs) toward intracellular
signaling pathways has been proposed to have physiological and pathological importance …

Ghrelin is a hormone produced in the gastrointestinal tract that acts via the growth hormone
secretagogue receptor. In the central nervous system, ghrelin signalling is able to recruit …

This paper is a personal account on the discovery and characterization of the 5-HT 2C
receptor (first known as the 5-HT 1C receptor) over 30 years ago and how it translated into a …

C/D box snoRNAs (SNORDs) are an abundantly expressed class of short, non‐coding
RNAs that have been long known to perform 2′‐O‐methylation of rRNAs. However …

Although often referred to as a hunger hormone, recent evidence highlights a
neuroprotective function of acylated ghrelin (AG) and a substantial role in the regulation of …