The RAS-ERK pathway is a fundamental signaling cascade crucial for many biological
processes including proliferation, cell cycle control, growth, and survival; common across all …

Introduction Recent years have seen significant strides in drug developmenttargeting the
EGFR/RAS/RAF signaling pathway which is critical forcell growth and proliferation. Protein …

Proteolysis targeting chimera (PROTAC) technology has become a powerful strategy in drug
discovery, especially for undruggable targets/proteins. A typical PROTAC degrader consists …

The Food and Drug Administration (FDA) has approved MAPK inhibitors as a treatment for
melanoma patients carrying a mutation in codon V600 of the BRAF gene exclusively …

Directly targeted KRAS inhibitors are now facing resistance problems, which might be
partially solved by the combination of SOS1 inhibitors with KRAS inhibitors. However, this …

Results: STK11 mutation could accelerate proliferation of LUAD cells and impact activity of
CD4+ T cells. Further research found that STK11 mutation affected tumor proliferation by …

Thanks to the development of molecular targeted therapy in recent years, the prognosis of
non-small cell lung cancer (NSCLC) patients has significantly improved. V-raf murine …