The most potent natural pharmaceuticals, cosmetics, and food ingredients isolated from plants with deep eutectic solvents

A Wawoczny, D Gillner - Journal of Agricultural and Food …, 2023 - ACS Publications
There is growing interest in reducing the number of synthetic products or additives and
replacing them with natural ones. The pharmaceutical, cosmetic, and food industries are …

Therapeutic benefits of flavonoids against neuroinflammation: a systematic review

Hamsalakshmi, AM Alex, M Arehally Marappa… - …, 2022 - Springer
Flavonoids are an important class of natural polyphenolic compounds reported to exert
beneficial effects in cardiovascular and metabolic diseases, cancer, autoimmune and …

Investigation of the effects of hesperidin administration on abamectin‐induced testicular toxicity in rats through oxidative stress, endoplasmic reticulum stress …

C Gur, O Kandemir, FM Kandemir - Environmental Toxicology, 2022 - Wiley Online Library
In this study, the potential effects of hesperidin (HES) on chronic toxicity caused by
abamectin (ABM) in the testicular tissue were investigated through oxidative stress …

Rutin protects rat liver and kidney from sodium valproate-induce damage by attenuating oxidative stress, ER stress, inflammation, apoptosis and autophagy

FM Kandemir, M Ileriturk, C Gur - Molecular biology reports, 2022 - Springer
Background The present study investigated the effects of rutin (RUT), which has various
biological and pharmacological properties, on liver and kidney damage caused by histone …

Quercetin provides protection against the peripheral nerve damage caused by vincristine in rats by suppressing caspase 3, NF-κB, ATF-6 pathways and activating …

A Yardim, FM Kandemir, S Ozdemir, S Kucukler… - Neurotoxicology, 2020 - Elsevier
In the present study, the protective effects of quercetin on peripheral neurotoxicity caused by
vincristine, which is used effectively in the treatment of various types of cancers, were …

The protective effects of hesperidin against paclitaxel-induced peripheral neuropathy in rats

HS Semis, FM Kandemir, O Kaynar, T Dogan… - Life Sciences, 2021 - Elsevier
Paclitaxel (PTX), which is widely used in the treatment of solid tumors, leads to dose
limitation because it causes peripheral neuropathy. This study was conducted to evaluate …

Novel inhibitors with sulfamethazine backbone: synthesis and biological study of multi-target cholinesterases and α-glucosidase inhibitors

C Türkeş, S Akocak, M Işık, N Lolak… - Journal of …, 2022 - Taylor & Francis
The underlying cause of many metabolic diseases is abnormal changes in enzyme activity
in metabolism. Inhibition of metabolic enzymes such as cholinesterases (ChEs; …

Evaluation of therapeutic effects of quercetin against Achilles tendinopathy in rats via oxidative stress, inflammation, apoptosis, autophagy, and metalloproteinases

HS Semis, C Gur, M Ileriturk… - … American journal of …, 2022 - journals.sagepub.com
Background: Achilles tendinopathy, seen in athletes and manual labor workers, is an
inflammatory condition characterized by chronic tendon pain. Owing to the toxicity that …

Morin protects against acrylamide-induced neurotoxicity in rats: an investigation into different signal pathways

C Gur, FM Kandemir, E Darendelioglu… - … Science and Pollution …, 2021 - Springer
The presented study investigates the effects of morin against toxicity induced by acrylamide
(ACR) in the brains of Sprague Dawley rats. In this study, neurotoxicity was induced by orally …

Morin attenuates acrylamide-induced testicular toxicity in rats by regulating the NF-κB, Bax/Bcl-2 and PI3K/Akt/mTOR signaling pathways

S Kucukler, C Caglayan, E Darendelioğlu… - Life Sciences, 2020 - Elsevier
Aim Acrylamide (AC) is a carcinogenic substance which is formed during the heating of
starchy foods at high temperatures and constitutes an important risk for human health …