Whether phase-separation is involved in the organization of the transcriptional machinery
and if it aids or inhibits the transcriptional process is a matter of intense debate. In this Mini …

Highlights•Transcriptional components can form dense assemblies termed condensates.•
Transcriptional condensates arise from interactions among proteins, RNA, or …

Chromatin loops, which bring two distal loci of the same chromosome into close physical
proximity, are the ubiquitous units of the three-dimensional genome. Recent advances in …

The inclusion of microexons by alternative splicing is frequent in neuronal proteins. The
roles of these sequences are in most cases unknown, but changes in their degree of …

Pioneer factors are a subclass of transcription factors that can bind and initiate opening of
silent chromatin regions. Pioneer factors subsequently regulate lineage-specific genes and …

Transcriptional enhancers control spatiotemporal gene expression and commonly engage
in long-range chromosomal contacts with gene promoters. However, the relationship …