The histone variant H2A. Z is involved in several processes such as transcriptional control,
DNA repair, regulation of centromeric heterochromatin and, not surprisingly, is implicated in …

Histones wrap DNA to form nucleosome particles that compact eukaryotic genomes. Variant
histones have evolved crucial roles in chromosome segregation, transcriptional regulation …

Genome-wide identification of the mechanism of action (MoA) of small-molecule compounds
characterizing their targets, effectors, and activity modulators represents a highly relevant yet …

Abstract H2A. Z is an essential histone variant implicated in the regulation of key nuclear
events. However, the metazoan chaperones responsible for H2A. Z deposition and its …

Protein post-translation modification plays an important role in regulating DNA repair;
however, the role of arginine methylation in this process is poorly understood. Here we …

Cancer is a complex disease characterized by loss of cellular homeostasis through genetic
and epigenetic alterations. Emerging evidence highlights a role for histone variants and their …

The repair of DNA double-strand breaks (DSBs) requires open, flexible chromatin domains.
The NuA4–Tip60 complex creates these flexible chromatin structures by exchanging histone …

The two closely related AAA+ family ATPases Rvb1 and Rvb2 are part of several critical
multiprotein complexes, and, thus, are involved in a wide range of cellular processes …

Many co-regulator proteins are recruited by DNA-bound transcription factors to remodel
chromatin and activate transcription. However, mechanisms for coordinating actions of …

Abstract H2A. Z is a highly conserved histone variant in all species. The chromatin
deposition of H2A. Z is specifically catalyzed by the yeast chromatin remodeling complex …