Abstract Treatment resistance to the antidepressive pharmacotherapy represents one of the
most important clinical challenges in the pharmacological management of unipolar …

Dopamine is a biologically active amine synthesized in the central and peripheral nervous
system. This biogenic monoamine acts by activating five types of dopamine receptors (D1 …

This naturalistic European multicenter study aimed to elucidate the association between
major depressive disorder (MDD) and comorbid anxiety disorders. Demographic and clinical …

Zusammenfassung Auf einen Blick Zusammenfassung Mit weit über 2 Milliarden DDD
stellen die Psychopharmaka eine der größten Arzneimittelgruppen dar. Dabei sind die seit …

Abstract● Introduction● Methods for proteomic analysis–Sample fractionation/biochemical
fractionation–MS● The cholesterol system–Cholesterol and apolipoproteins–Cholesterol …

Abstract Background: Antidepressants (ADs) are known to have the potential to cause
various cardiovascular adverse drug reactions (ADRs). The tricyclic antidepressants (TCAs) …

Background: Drug-induced liver injury is a common cause of liver damage and the most
frequent reason for withdrawal of a drug in the United States. The symptoms of drug-induced …

Major depressive disorder is one of the most prevalent and life-threatening forms of mental
illnesses and a major cause of morbidity worldwide. Currently available antidepressants are …

Antipsychotic (AP) medications are associated with an increased risk of developing
metabolic side effects including weight gain, type 2 diabetes (T2D), dyslipidemia, and …

Given the huge symptom diversity and complexity of mental disorders, an individual
approach is the most promising avenue for clinical transfer and the establishment of …