Contrary to the commonly held misconception, bone is a relatively dynamic organ that
undergoes significant turnover as compared to other organs in the body. This review details …

Mesenchymal stem cells (MSCs) are multipotent cells that arise from the mesenchyme
during development. They reside in the bone marrow close to hematopoietic stem cell …

Mesenchymal stem cells (MSCs) transplanted at sites of nerve injury are thought to promote
functional recovery by producing trophic factors that induce survival and regeneration of host …

The tremendous capacity of bone to regenerate is indicative of the presence of stem cells
with the capability, by definition, to self-renew as well as to give rise to daughter cells. These …

The basic molecular characteristics of intervertebral disc cells are still poorly defined. This
study compared the phenotypes of nucleus pulposus (NP), annulus fibrosus (AF) and …

Molecular mechanisms and consequences of angiogenesis in osteoarthritis are slowly
being elucidated. Studies, both in humans and animal models, support the notion that …

Bone marrow (BM) is a source of hematopoietic stem cells (HSCs). HSCs are localized in
both the endosteum, in the so-called endosteal niche, and close to thin-walled and …

Introduction Peyronie disease (PD) is a progressive fibrotic disorder of the penile tunica
albuginea that results in fibrotic penile plaques and can lead to penile deformity …

The human osteosarcoma cell line Saos-2 is widely used as a model system for human
osteoblastic cells, though its phenotypic stability has not been ascertained. We therefore …

OBJECTIVES: To compare the gene expression alterations in human Peyronie's disease
(PD) and Dupuytren's disease (DD) to determine whether they share a common …