A vast evolutionarily transient translatome contributes to phenotype and fitness
Translation is the process by which ribosomes synthesize proteins. Ribosome profiling
recently revealed that many short sequences previously thought to be noncoding are …
recently revealed that many short sequences previously thought to be noncoding are …
Biological factors and statistical limitations prevent detection of most noncanonical proteins by mass spectrometry
A Wacholder, AR Carvunis - PLoS Biology, 2023 - journals.plos.org
Ribosome profiling experiments indicate pervasive translation of short open reading frames
(ORFs) outside of annotated protein-coding genes. However, shotgun mass spectrometry …
(ORFs) outside of annotated protein-coding genes. However, shotgun mass spectrometry …
DBP7 and YRF1-6 Are Involved in Cell Sensitivity to LiCl by Regulating the Translation of PGM2 mRNA
SK Jagadeesan, M Al-Gafari, J Wang… - International Journal of …, 2023 - mdpi.com
Lithium chloride (LiCl) has been widely researched and utilized as a therapeutic option for
bipolar disorder (BD). Several pathways, including cell signaling and signal transduction …
bipolar disorder (BD). Several pathways, including cell signaling and signal transduction …
Lithium chloride sensitivity in yeast and regulation of translation
M Hajikarimlou, K Hunt, G Kirby, S Takallou… - International Journal of …, 2020 - mdpi.com
For decades, lithium chloride (LiCl) has been used as a treatment option for those living with
bipolar disorder (BD). As a result, many studies have been conducted to examine its mode …
bipolar disorder (BD). As a result, many studies have been conducted to examine its mode …
Discovery and identification of genes involved in DNA damage repair in yeast
SK Jagadeesan, T Potter, M Al-Gafari, M Hooshyar… - Gene, 2022 - Elsevier
DNA repair defects are common in tumour cells and can lead to misrepair of double-strand
breaks (DSBs), posing a significant challenge to cellular integrity. The overall mechanisms …
breaks (DSBs), posing a significant challenge to cellular integrity. The overall mechanisms …
Lithium chloride sensitivity connects the activity of PEX11 and RIM20 to the translation of PGM2 and other mRNAs with structured 5'-UTRs
SK Jagadeesan, M Al-Gafari, M Hajikarimlou… - Molecular and Cellular …, 2022 - Springer
Lithium chloride (LiCl) is a widely used and extensively researched drug for the treatment of
bipolar disorder (BD). As a result, LiCl has been the subject of research studying its toxicity …
bipolar disorder (BD). As a result, LiCl has been the subject of research studying its toxicity …
Modified Phenol/Chloroform‐Free DNA Isolation from Yeast and Other Fungi by Non‐Enzymatic Salting Out Method
The most commonly used fungal DNA extraction techniques require enzymatic digestion or
hazardous chemicals. Here, we describe a quick non‐enzymatic salt‐out method that we …
hazardous chemicals. Here, we describe a quick non‐enzymatic salt‐out method that we …
Rare detection of noncanonical proteins in yeast mass spectrometry studies
A Wacholder, AR Carvunis - Biorxiv, 2023 - biorxiv.org
Ribosome profiling experiments indicate pervasive translation of short open reading frames
(ORFs) outside of annotated protein-coding genes. However, shotgun mass spectrometry …
(ORFs) outside of annotated protein-coding genes. However, shotgun mass spectrometry …
[HTML][HTML] Investigating the Activities of CAF20 and ECM32 in the Regulation of PGM2 mRNA Translation
M Al-gafari, SK Jagadeesan, TDD Kazmirchuk… - Biology, 2024 - mdpi.com
Translation is a fundamental process in biology, and understanding its mechanisms is
crucial to comprehending cellular functions and diseases. The regulation of this process is …
crucial to comprehending cellular functions and diseases. The regulation of this process is …
[PDF][PDF] A reference translatome map reveals two modes of protein evolution
A Wacholder12, O Acar123, AR Carvunis12 - 2021 - academia.edu
Ribosome profiling experiments demonstrate widespread translation of eukaryotic genomes
outside of 12 annotated protein-coding genes. However, it is unclear how much of this …
outside of 12 annotated protein-coding genes. However, it is unclear how much of this …