The exploration of privileged structures in drug discovery is a rapidly emerging theme in
medicinal chemistry. These structures represent a class of molecules capable of binding to …

With the recent emergence of combinatorial chemistry and high-speed parallel synthesis for
drug discovery applications, the multi-component reaction (MCR) has seen a resurgence of …

With the emergence of high‐throughput screening in the pharmaceutical industry in the early
1990's, organic chemists were faced with a new challenge: how to prepare large collections …

A new, efficient, one-pot multicomponent reaction for the synthesis of diazepine derivatives
in excellent yields is described. The reactions of various 1, 2-diamines, terminal alkynes …

Benzodiazepines (BZDs), a diverse class of benzofused seven-membered N-heterocycles,
display essential pharmacological properties and play vital roles in some biochemical …

The efficacy of isocyanide reactions in the synthesis of natural or naturallike products has
resulted in a renaissance of isocyanide chemistry. Now isocyanides are widely used in …

A new 4-point pharmacophore method for molecular similarity and diversity that rapidly
calculates all potential pharmacophores/pharmacophoric shapes for a molecule or a protein …

A new biopolymer-based magnetic nanocomposite was prepared and characterized by
Fourier transform infrared (FT-IR) spectroscopy, energy-dispersive X-ray (EDX) analysis …

A library of 1, 4-benzodiazepine-2, 5-diones was screened for binding to the p53-binding
domain of HDM2 using Thermofluor®, a miniaturized thermal denaturation assay. The hits …

A novel multicomponent synthesis of 5-aminooxazole starting from simple and readily
available inputs is described. Thus, simply heating a methanol solution of an aldehyde 3, an …