Mild therapeutic hypothermia is considered standard care in the treatment of patients
resuscitated from cardiac arrest. With increasingly more frequent concomitant use of platelet …

The integrin family of cell surface receptors integrates cell-extracellular matrix interactions
with the cell cytoskeleton and signalling across the cell membrane, resulting in an important …

Molecular forces generated by cell receptors are infrequent and transient, and hence difficult
to detect. Here we report an assay that leverages the CRISPR-associated protein 12a …

Cells transmit piconewton forces to receptors to mediate processes such as migration and
immune recognition. A major challenge in quantifying such forces is the sparsity of cell …

Mechanotransduction, the interplay between physical and chemical signaling, plays vital
roles in many biological processes. The state‐of‐the‐art techniques to quantify cell forces …

Bleeding is the most common and serious adverse effect of currently available antiplatelet
drugs. Many efforts are being made to develop novel antithrombotic agents without bleeding …

GPIIb/IIIa receptor antagonists block fibrinogen binding to platelets and as a result inhibit
platelet aggregation. They are very potent inhibitors due to the critical role fibrinogen binding …

The Impact [cone and plate (let) analyzer (CPA) Technology] is testing whole blood platelet
adhesion and aggregation under arterial flow conditions. The adhered platelets are stained …

Objective To review the current in vivo and in vitro tests of platelet function (PF) currently
available and applicable to companion animals. Data Sources Scientific reviews, case …

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