Glioblastoma (GBM) is a devastating type of brain tumor, and current therapeutic treatments,
including surgery, chemotherapy, and radiation, are palliative at best. The design of effective …

Patients with glioblastoma (GBM) have a universally poor prognosis and are in urgent need
of effective treatment strategies. Recent advances in sequencing techniques unraveled the …

Overcoming metabolic stress is a critical step in tumor growth. Acetyl coenzyme A (acetyl-
CoA) generated from glucose and acetate uptake is important for histone acetylation and …

Tumor-specific pyruvate kinase M2 (PKM2) is essential for the Warburg effect. In addition to
its well-established role in aerobic glycolysis, PKM2 directly regulates gene transcription …

The embryonic pyruvate kinase M2 (PKM2) isoform is highly expressed in human cancer. In
contrast to the established role of PKM2 in aerobic glycolysis or the Warburg effect,,, its non …

Pyruvate kinase M2 isoform (PKM2) catalyzes the last step of glycolysis and plays an
important role in tumor cell proliferation. Recent studies have reported that PKM2 also …

Abstract Phosphofructokinase 1 (PFK1) plays a critical role in glycolysis; however, its role
and regulation in tumorigenesis are not well understood. Here, we demonstrate that PFK1 …

PD-L1 up-regulation in cancer contributes to immune evasion by tumor cells. Here, we show
that Wnt ligand and activated EGFR induce the binding of the β-catenin/TCF/LEF complex to …

Autophagy is crucial for maintaining cell homeostasis. However, the precise mechanism
underlying autophagy initiation remains to be defined. Here, we demonstrate that glutamine …

Bevacizumab, an antibody against vascular endothelial growth factor (VEGF), is a
promising, yet controversial, drug in human glioblastoma treatment (GBM). Its effects on …