Introduction Polypharmacy is commonly associated with adverse health outcomes. There
are currently no meta-analyses of the prevalence of polypharmacy or factors associated with …

Background It has been shown that antiepileptic drugs (AEDs) may have a detrimental effect
on bone health and translate into an increased risk of bone fracture. We aimed to …

Background and objective Laboratories sometimes use different reference ranges for the
same antiepileptic drug (AED), particularly for new and poorly investigated drugs. This may …

Objective To provide first data on the cost of epilepsy and cost‐driving factors in children,
adolescents, and their caregivers in Germany. Methods A population‐based, cross …

Objective To assess the relative risk of oral clefts associated with maternal use of high and
low doses of topiramate during the first trimester for epilepsy and nonepilepsy indications …

The occurrence of hypersensitivity reactions including rare but life‐threatening Stevens–
Johnson syndrome (SJS) and drug‐induced hypersensitivity syndrome (HSS) limits the use …

Phenobarbital (phenobarbitone) was first used as an antiepileptic drug 100 years ago, in
1912. This article tells the story of the discovery of its antiepileptic action, its early …

Objective The goal of this study was to determine the effects of mono-, bi-, and polytherapy
anti-seizure medications (ASMs) in terms of seizure reduction and quality of life (QOL) in …

This review focuses on the evolution of approaches to dosing of antiepileptic drugs (AEDs)
in clinical practice through history. There has been a shift in the view of treatment of …

Antiseizure medications (ASMs) are the cornerstone of treatment for patients with epilepsy.
Several new ASMs have recently been introduced to the market, making it possible to better …