The mononuclear molybdenum enzymes
Molybdenum is the only second-row transition metal required by most living organisms, and
is nearly universally distributed in biology. Enzymes containing molybdenum in their active …
is nearly universally distributed in biology. Enzymes containing molybdenum in their active …
Xanthine oxidase inhibitors beyond allopurinol and febuxostat; an overview and selection of potential leads based on in silico calculated physico-chemical properties …
A Šmelcerović, K Tomović, Ž Šmelcerović… - European journal of …, 2017 - Elsevier
Xanthine oxidase (XO), a versatile metalloflavoprotein enzyme, catalyzes the oxidative
hydroxylation of hypoxanthine and xanthine to uric acid in purine catabolism while …
hydroxylation of hypoxanthine and xanthine to uric acid in purine catabolism while …
Computational characterization of the inhibition mechanism of xanthine oxidoreductase by topiroxostat
Xanthine oxidase (XO) is a member of the molybdopterin-containing enzyme family. It
interconverts xanthine to uric acid as the last step of purine catabolism in the human body …
interconverts xanthine to uric acid as the last step of purine catabolism in the human body …
Mechanistic insights into xanthine oxidoreductase from development studies of candidate drugs to treat hyperuricemia and gout
T Nishino, K Okamoto - JBIC Journal of Biological Inorganic Chemistry, 2015 - Springer
Xanthine oxidoreductase (XOR), which is widely distributed from humans to bacteria, has a
key role in purine catabolism, catalyzing two steps of sequential hydroxylation from …
key role in purine catabolism, catalyzing two steps of sequential hydroxylation from …
Mutations associated with functional disorder of xanthine oxidoreductase and hereditary xanthinuria in humans
K Ichida, Y Amaya, K Okamoto, T Nishino - International journal of …, 2012 - mdpi.com
Xanthine oxidoreductase (XOR) catalyzes the conversion of hypoxanthine to xanthine and
xanthine to uric acid with concomitant reduction of either NAD+ or O2. The enzyme is a …
xanthine to uric acid with concomitant reduction of either NAD+ or O2. The enzyme is a …
Identification of new drug-like compounds from millets as Xanthine oxidoreductase inhibitors for treatment of Hyperuricemia: A molecular docking and simulation study
Xanthine oxidoreductase plays an important role in formation of uric acid and its regulation
during purine catabolism. Uncontrolled expression of this enzyme is responsible for …
during purine catabolism. Uncontrolled expression of this enzyme is responsible for …
[HTML][HTML] Inhibition of xanthine oxidase alleviated pancreatic necrosis via HIF-1α-regulated LDHA and NLRP3 signaling pathway in acute pancreatitis
J Rong, C Han, Y Huang, Y Wang, Q Qiu… - … Pharmaceutica Sinica B, 2024 - Elsevier
Acute pancreatitis (AP) is a potentially fatal condition with no targeted treatment options.
Although inhibiting xanthine oxidase (XO) in the treatment of AP has been studied in several …
Although inhibiting xanthine oxidase (XO) in the treatment of AP has been studied in several …
Association of mutations identified in xanthinuria with the function and inhibition mechanism of xanthine oxidoreductase
M Sekine, K Okamoto, K Ichida - Biomedicines, 2021 - mdpi.com
Xanthine oxidoreductase (XOR) is an enzyme that catalyzes the two-step reaction from
hypoxanthine to xanthine and from xanthine to uric acid in purine metabolism. XOR …
hypoxanthine to xanthine and from xanthine to uric acid in purine metabolism. XOR …
Screening, isolation, and activity evaluation of potential xanthine oxidase inhibitors in Poria Cum Radix Pini and mechanism of action in the treatment of gout disease
S Zhuang, H Yun, X Zhou, Y Li, S Li… - Journal of Separation …, 2024 - Wiley Online Library
Poria Cum Radix Pini is a rare medicinal fungus that contains several potential therapeutic
ingredients. On this basis, a particle swarm mathematical model was used to optimize the …
ingredients. On this basis, a particle swarm mathematical model was used to optimize the …
XDH and XO research and drug discovery—Personal history
T Nishino - Molecules, 2023 - mdpi.com
The author will outline the research history of the main issues addressed in this paper. The
author has worked on this research himself. XDH, which is responsible for purine …
author has worked on this research himself. XDH, which is responsible for purine …