Acetylation is one of the major post-translational protein modifications in the cell, with
manifold effects on the protein level as well as on the metabolome level. The acetyl group …

More and more in-depth studies have revealed that the occurrence and development of
tumors depend on gene mutation and tumor heterogeneity. The most important …

Metabolic reprogramming is involved in the pathogenesis of not only cancers but also
neurodegenerative diseases, cardiovascular diseases, and infectious diseases. With the …

Metabolism and gene expression, which are two fundamental biological processes that are
essential to all living organisms, reciprocally regulate each other to maintain homeostasis …

Histones are DNA‐binding basic proteins found in chromosomes. After the histone
translation, its amino tail undergoes various modifications, such as methylation, acetylation …

Background Many metabolites serve as important signalling molecules to adjust cellular
activities and functions based on nutrient availability. Links between acetyl-CoA metabolism …

Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Epigenetic regulation of gene expression is a dynamic and reversible process that
establishes normal cellular phenotypes but also contributes to human diseases. At the …

Protein lysine acetylation is an important posttranslational modification that regulates
numerous biological processes. Targeting lysine acetylation regulatory factors, such as …

Several mechanisms have been proposed for histone marks to exert their functions,
including altering the physical properties of nucleosomes by neutralization of charge via …