The global epidemic of Alzheimer disease (AD) is worsening, and no approved treatment
can revert or arrest progression of this disease. AD pathology is characterized by the …

Emodin is an anthraquinone derivative found in the roots and bark of a variety of plants,
molds, and lichens. Emodin has been used as a traditional medication for more than 2000 …

The coexistence of amyloid-β (Aβ) plaques and tau neurofibrillary tangles in the neocortex is
linked to neural system failure and cognitive decline in Alzheimer's disease. However, the …

Accumulation of amyloid‐β (Aβ) and fibrillary tangles, as well as neuroinflammation and
memory loss, are hallmarks of Alzheimer's disease (AD). After almost 15 years from their …

This review of Alzheimer's disease assembles a variety of findings relevant to the
mechanism of the disease and ties them together using the current understanding of the …

Alzheimer's disease (AD), the leading cause of dementia worldwide, is characterized by the
accumulation of the β-amyloid peptide (Aβ) within the brain along with hyperphosphorylated …

Disease-modifying treatments for Alzheimer disease (AD) have focused mainly on reducing
levels of amyloid-β (Aβ) in the brain. Some compounds have achieved this goal, but none …

Tau is the major microtubule associated protein (MAP) of a mature neuron. The other two
neuronal MAPs are MAP1 and MAP2. An established function of MAPs is their interaction …

The microtubule-associated protein tau accumulates in Alzheimer's and other fatal
dementias, which manifest when forebrain neurons die. Recent advances in understanding …

Neurofibrillary tangles and amyloid plaques constitute the hallmark brain lesions of
Alzheimer's disease (AD) patients. Tangles are composed of fibrillar aggregates of the …