The landmark discoveries of leptin and adiponectin firmly established adipose tissue as a
sophisticated and highly active endocrine organ, opening a new era of investigating adipose …

Adiponectin is the most abundant peptide secreted by adipocytes, whose reduction plays a
central role in obesity-related diseases, including insulin resistance/type 2 diabetes and …

Adiponectin, first described in the mid-1990s, is one of the most widely studied adipokines to
date. Studies of its regulation, biogenesis and physiological effects have yielded great …

Obesity-linked type 2 diabetes is one of the paramount causes of morbidity and mortality
worldwide, posing a major threat on human health, productivity, and quality of life. Despite …

Adipose tissue is a major source of energy for the human body. It is also a source of major
adipocytokines adiponectin and leptin. Insulin resistance is a condition in which insulin …

Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases
worldwide, as it affects up to 30% of adults in Western countries. Moreover, NAFLD is also …

Vascular endothelial cells (ECs) senescence correlates with the increase of cardiovascular
diseases in ageing population. Although ECs rely on glycolysis for energy production, little is …

Improving physical function and mobility in a continuously expanding elderly population
emerges as a high priority of medicine today. Muscle mass, strength/power, and maximal …

FGF21, a member of the fibroblast growth factor (FGF) superfamily, has recently emerged as
a regulator of metabolism and energy utilization. However, the exact mechanism (s) …

Metabolic syndrome is thought to result from obesity and obesity-linked insulin resistance.
Obesity in adulthood is characterized by adipocyte hypertrophy. Adipose tissue participates …