[HTML][HTML] Synaptic plasticity abnormalities in fetal alcohol spectrum disorders

BS Basavarajappa, S Subbanna - Cells, 2023 - mdpi.com
The brain's ability to strengthen or weaken synaptic connections is often termed synaptic
plasticity. It has been shown to function in brain remodeling following different types of brain …

Epigenetics in fetal alcohol spectrum disorder

BS Basavarajappa - Progress in Molecular Biology and Translational …, 2023 - Elsevier
During pregnancy, alcohol abuse and its detrimental effects on developing offspring are
major public health, economic and social challenges. The prominent characteristic attributes …

The development of advanced structural framework as multi-target-directed ligands for the treatment of Alzheimer's disease

Z Sang, K Wang, J Shi, W Liu, X Cheng, G Zhu… - European Journal of …, 2020 - Elsevier
In this work, we have developed a novel series of multi-target-directed ligands to address
low levels of acetylcholine (ACh), oxidative stress, metal ion dysregulation, and the …

[HTML][HTML] Effects of genetics and sex on acute gene expression changes in the hippocampus following neonatal ethanol exposure in BXD recombinant inbred mouse …

JA Baker, JT Brettin, MK Mulligan, KM Hamre - Brain Sciences, 2022 - mdpi.com
Fetal alcohol spectrum disorders (FASD) are prevalent neurodevelopmental disorders.
Genetics have been shown to have a role in the severity of alcohol's teratogenic effects on …

Chronic alcohol exposure alters gene expression and neurodegeneration pathways in the brain of adult mice

M Liu, S Guo, D Huang, D Hu, Y Wu… - Journal of …, 2022 - content.iospress.com
Background: Chronic alcohol consumption can alter the structure of the central nervous
system and disrupt cognitive function. Alcoholics are more likely to develop …

Prenatal alcohol exposure reduces posterior dorsomedial striatum excitability and motivation in a sex-and age-dependent fashion

V Roselli, C Guo, D Huang, D Wen, D Zona, T Liang… - …, 2020 - Elsevier
Prenatal alcohol exposure (PAE)-induced clinical symptoms have been widely reported but
effective treatments are not yet available due to our limited knowledge of the neuronal …

Microglia and astrocytes show limited, acute alterations in morphology and protein expression following a single developmental alcohol exposure

RL Lowery, MKY Cealie, CE Lamantia… - Journal of …, 2021 - Wiley Online Library
Fetal alcohol spectrum disorders (FASD) are the most common cause of nonheritable,
preventable mental disability and are characterized by cognitive, behavioral, and physical …

Morphological alteration in rat hippocampal neuronal dendrites following chronic binge prenatal alcohol exposure

J Lee, V Naik, M Orzabal, R Lunde-Young… - Brain research, 2021 - Elsevier
Prenatal alcohol exposure (PAE) may result in Fetal Alcohol Spectrum Disorders (FASD).
The hippocampus has been recognized as a vulnerable target to alcohol-induced …

Embryonic alcohol exposure alters cholinergic neurotransmission and memory in adult zebrafish

BFG Gamba, K de Pieri Pickler, G Lodetti… - Behavioural Brain …, 2024 - Elsevier
Alcohol is the most consumed addictive substance worldwide that elicits multiple health
problems. Consumption of alcoholic beverages by pregnant women is of great concern …

Gene expression profiling in the hippocampus of adolescent rats after chronic alcohol administration

MR Choi, JS Han, YG Chai, YB Jin… - Basic & Clinical …, 2020 - Wiley Online Library
Abstract In South Korea, the average age of onset of alcohol drinking is 13.3 years and half
of adolescents drink alcohol more than once a month; 8.45% of the Korean adolescent …