Hyperinsulinemia and its pivotal role in aging, obesity, type 2 diabetes, cardiovascular disease and cancer

JA Janssen - International journal of molecular sciences, 2021 - mdpi.com
For many years, the dogma has been that insulin resistance precedes the development of
hyperinsulinemia. However, recent data suggest a reverse order and place …

The pathophysiology of gestational diabetes mellitus

JF Plows, JL Stanley, PN Baker, CM Reynolds… - International journal of …, 2018 - mdpi.com
Gestational diabetes mellitus (GDM) is a serious pregnancy complication, in which women
without previously diagnosed diabetes develop chronic hyperglycemia during gestation. In …

Differentiation of diabetes by pathophysiology, natural history, and prognosis

JS Skyler, GL Bakris, E Bonifacio, T Darsow… - Diabetes, 2017 - Am Diabetes Assoc
The American Diabetes Association, JDRF, the European Association for the Study of
Diabetes, and the American Association of Clinical Endocrinologists convened a research …

Psychological stress, intestinal barrier dysfunctions, and autoimmune disorders: an overview

H Ilchmann-Diounou, S Menard - Frontiers in immunology, 2020 - frontiersin.org
Autoimmune disorders (ADs) are multifactorial diseases involving, genetic, epigenetic, and
environmental factors characterized by an inappropriate immune response toward self …

Gut microbiota, immune development and function

S Bengmark - Pharmacological research, 2013 - Elsevier
The microbiota of Westerners is significantly reduced in comparison to rural individuals
living a similar lifestyle to our Paleolithic forefathers but also to that of other free-living …

Streptozotocin‐induced diabetes models: Pathophysiological mechanisms and fetal outcomes

DC Damasceno, AO Netto, IL Iessi… - BioMed research …, 2014 - Wiley Online Library
Glucose homeostasis is controlled by endocrine pancreatic cells, and any pancreatic
disturbance can result in diabetes. Because 8% to 12% of diabetic pregnant women present …

The elevated susceptibility to diabetes in India: an evolutionary perspective

JCK Wells, E Pomeroy, SR Walimbe… - Frontiers in public …, 2016 - frontiersin.org
India has rapidly become a “diabetes capital” of the world, despite maintaining high rates of
under-nutrition. Indians develop diabetes at younger age and at lower body weights than …

Emerging therapeutic options in the management of diabetes: recent trends, challenges and future directions

MA Ansari, W Chauhan, S Shoaib… - International Journal of …, 2023 - nature.com
Diabetes is a serious health issue that causes a progressive dysregulation of carbohydrate
metabolism due to insufficient insulin hormone, leading to consistently high blood glucose …

Impact of early nutrition, physical activity and sleep on the fetal programming of disease in the pregnancy: a narrative review

J Moreno-Fernandez, JJ Ochoa, M Lopez-Frias… - Nutrients, 2020 - mdpi.com
Early programming is the adaptation process by which nutrition and environmental factors
alter development pathways during prenatal growth, inducing changes in postnatal …

Obesity as malnutrition: the role of capitalism in the obesity global epidemic

JCK Wells - American Journal of Human Biology, 2012 - Wiley Online Library
The global obesity epidemic remains poorly understood, partly because it has emerged
alongside persisting under‐nutrition in many populations. At an abstract level, obesity …