Disordered metabolic states, which are characterised by hypoxia and elevated levels of
metabolites, particularly lactate, contribute to the immunosuppression in the tumour …

As a result of metabolic reprogramming, cancer cells display high rates of glycolysis,
causing an excess production of lactate along with an increase in extracellular acidity …

Lactate has long been considered as a metabolic by-product of aerobic glycolysis for
cancer. However, more and more studies have shown that lactate can regulate cancer …

Doxorubicin (Dox) is widely used in chemotherapy regimens for several malignant
conditions. Unfortunately, cumulative and irreversible cardiotoxicity of Dox is the most …

Metformin is a widely used antidiabetic drug for cancer prevention and treatment. However,
the overproduction of lactic acid and its inefficiency in cancer therapy limit its application …

The incidence of cancer is increasing dramatically, affecting all ages of the population and
reaching an ever higher worldwide mortality rate. The lack of therapies' efficacy is due to …

Hypercholesterolemia is often correlated with obesity which is considered a risk factor for
various cancers. With the growing population of hypercholesterolemic individuals, there is a …

Aims High-mobility group (HMG) proteins are oncogenic in different cancers, including
cervical cancer; silencing their individual expression using sh-RNAs, siRNAs, and miRNAs …

Multidrug resistance (MDR) is currently a big challenge in cancer therapy and limits its
success in several patients. Tumors use the MDR mechanisms to colonize the host and …

Significance: Cancer-associated tissue-specific lactic acidosis stimulates and mediates
tumor invasion and metastasis and is druggable. Rarely, malignancy causes systemic lactic …