We provide an overview of imaging, histopathology, genetics, and multidisciplinary
treatment of giant cell tumor of bone (GCTB), an intermediate, locally aggressive but rarely …

Giant cell tumor (GCT) of bone is a benign but locally aggressive tumor that usually involves
the end of long bone. Its histogenesis remains unclear. It is characterized by a proliferation …

The interaction between epithelial cancer cells and cancer-associated fibroblasts (CAFs)
has a major role in cancer progression and eventually in metastasis. In colorectal cancer …

Pericellular proteases play an important role in angiogenesis and vasculogenesis. They
comprise (membrane-type) matrix metalloproteinases [(MT-) MMPs], serine proteases …

Giant cell tumour of bone (GCTB) is an intermediate locally aggressive primary bone tumour,
occurring mostly at the meta-epiphysis of long bones. Overexpression of receptor activator of …

Objective: To discuss the treatment and outcomes for giant cell tumor (GCT) of bone.
Materials and Methods: Review of the pertinent literature. Results: GCT is a rare benign …

Metastasis to bone is a major cause of morbidity in breast cancer patients, emphasizing the
importance of identifying molecular drivers of bone metastasis for new therapeutic targets …

Cathepsin K is a highly potent collagenase and the predominant papain-like cysteine
protease expressed in osteoclasts. Cathepsin K deficiencies in humans and mice have …

Irreversible covalent inhibitors can have a beneficial pharmacokinetic/pharmacodynamics
profile but are still often avoided due to the risk of indiscriminate covalent reactivity and the …

Comprehending the pathogenesis of giant cell tumor of bone (GCT) is of critical importance
for developing novel targeted treatments for this locally-aggressive primary bone tumor. GCT …