Metabolic homeostasis operates differently in men and women. This sex asymmetry is the
result of evolutionary adaptations that enable women to resist loss of energy stores and …

Many aspects of metabolism are sex-biased, from gene expression in metabolic tissues to
the prevalence and presentation of cardiometabolic diseases. The influence of hormones …

Adaptations to infectious and dietary pressures shape mammalian physiology and disease
risk. How such adaptations affect sex-biased diseases remains insufficiently studied. In this …

Different organs undergo distinct transcriptional, epigenetic and physiological alterations
that guarantee their functional maturation after birth. However, the roles of epitranscriptomic …

Background: FTO (fat mass and obesity-associated protein) demethylates N 6-
methyladenosine (m6A), which is a critical epitranscriptomic regulator of neuronal function …

The zonation of liver metabolic processes is well-characterized; however, little is known
about the cell type-specificity and zonation of sexually dimorphic gene expression or its …

Chemical modifications of mRNA, the so-called epitranscriptome, represent an additional
layer of post-transcriptional regulation of gene expression. The most common …

The nuclear receptors liver X receptor (LXR) α and β play crucial roles in hepatic
metabolism. Many genes induced in response to pharmacologic LXR agonism have been …

Hepatic glycogen is the main source of blood glucose and controls the intervals between
meals in mammals. Hepatic glycogen storage in mammalian pups is insufficient compared …

Background As a primarily N6-methyladenosine methyltransferase, methyltransferase 3
(METTL3) plays a crucial role in nonalcoholic fatty liver disease. However, its regulatory …