Sex differences in energy metabolism: natural selection, mechanisms and consequences
F Mauvais-Jarvis - Nature Reviews Nephrology, 2024 - nature.com
Metabolic homeostasis operates differently in men and women. This sex asymmetry is the
result of evolutionary adaptations that enable women to resist loss of energy stores and …
result of evolutionary adaptations that enable women to resist loss of energy stores and …
The impact of chromosomal sex on cardiometabolic health and disease
CB Wiese, R Avetisyan, K Reue - Trends in Endocrinology & Metabolism, 2023 - cell.com
Many aspects of metabolism are sex-biased, from gene expression in metabolic tissues to
the prevalence and presentation of cardiometabolic diseases. The influence of hormones …
the prevalence and presentation of cardiometabolic diseases. The influence of hormones …
An evolutionary trade-off between host immunity and metabolism drives fatty liver in male mice
Adaptations to infectious and dietary pressures shape mammalian physiology and disease
risk. How such adaptations affect sex-biased diseases remains insufficiently studied. In this …
risk. How such adaptations affect sex-biased diseases remains insufficiently studied. In this …
m6A modification-tuned sphingolipid metabolism regulates postnatal liver development in male mice
S Wang, S Chen, J Sun, P Han, B Xu, X Li, Y Zhong… - Nature …, 2023 - nature.com
Different organs undergo distinct transcriptional, epigenetic and physiological alterations
that guarantee their functional maturation after birth. However, the roles of epitranscriptomic …
that guarantee their functional maturation after birth. However, the roles of epitranscriptomic …
Cerebroprotective Role of N6-Methyladenosine Demethylase FTO (Fat Mass and Obesity-Associated Protein) After Experimental Stroke
Background: FTO (fat mass and obesity-associated protein) demethylates N 6-
methyladenosine (m6A), which is a critical epitranscriptomic regulator of neuronal function …
methyladenosine (m6A), which is a critical epitranscriptomic regulator of neuronal function …
Interplay between GH-regulated, sex-biased liver transcriptome and hepatic zonation revealed by single-nucleus RNA sequencing
The zonation of liver metabolic processes is well-characterized; however, little is known
about the cell type-specificity and zonation of sexually dimorphic gene expression or its …
about the cell type-specificity and zonation of sexually dimorphic gene expression or its …
Alphaherpesvirus US3 protein-mediated inhibition of the m6A mRNA methyltransferase complex
RJJ Jansens, R Verhamme, AH Mirza… - Cell reports, 2022 - cell.com
Chemical modifications of mRNA, the so-called epitranscriptome, represent an additional
layer of post-transcriptional regulation of gene expression. The most common …
layer of post-transcriptional regulation of gene expression. The most common …
Integrative analysis reveals multiple modes of LXR transcriptional regulation in liver
L Bideyan, W Fan… - Proceedings of the …, 2022 - National Acad Sciences
The nuclear receptors liver X receptor (LXR) α and β play crucial roles in hepatic
metabolism. Many genes induced in response to pharmacologic LXR agonism have been …
metabolism. Many genes induced in response to pharmacologic LXR agonism have been …
N6-methyladenosine modification governs liver glycogenesis by stabilizing the glycogen synthase 2 mRNA
X Zhang, H Yin, X Zhang, X Jiang, Y Liu… - Nature …, 2022 - nature.com
Hepatic glycogen is the main source of blood glucose and controls the intervals between
meals in mammals. Hepatic glycogen storage in mammalian pups is insufficient compared …
meals in mammals. Hepatic glycogen storage in mammalian pups is insufficient compared …
[HTML][HTML] The methyltransferase METTL3-mediated fatty acid metabolism revealed the mechanism of cinnamaldehyde on alleviating steatosis
R Xu, X Xiao, S Zhang, J Pan, Y Tang, W Zhou… - Biomedicine & …, 2022 - Elsevier
Background As a primarily N6-methyladenosine methyltransferase, methyltransferase 3
(METTL3) plays a crucial role in nonalcoholic fatty liver disease. However, its regulatory …
(METTL3) plays a crucial role in nonalcoholic fatty liver disease. However, its regulatory …