99mTc-gallic-gold nanoparticles as a new imaging platform for tumor targeting
TM Sakr, MA El-Hashash, AA El-Mohty… - Applied Radiation and …, 2020 - Elsevier
Early and accurate detection of tumor assists in identifying more effective therapies. Gold
nanoparticles (GNPs) were synthesized by green synthesis method using gallic acid (GA) …
nanoparticles (GNPs) were synthesized by green synthesis method using gallic acid (GA) …
Conventional and microwave-assisted synthesis, anticancer evaluation, 99mTc-coupling and In-vivo study of some novel pyrazolone derivatives
New pyrazolone derivatives were successfully synthesized by both microwave-assisted and
conventional techniques. Compound 3 (3-(3-Methyl-5-oxo-4, 5-dihydro-1H-pyrazol-1-yl)-3 …
conventional techniques. Compound 3 (3-(3-Methyl-5-oxo-4, 5-dihydro-1H-pyrazol-1-yl)-3 …
Synthesis, characterization, radiolabeling and biodistribution of a novel cyclohexane dioxime derivative as a potential candidate for tumor imaging
MA Motaleb, AA Selim, M El-Tawoosy… - … journal of radiation …, 2018 - Taylor & Francis
Purpose: Dioxime derivative is reported to exhibit high affinity towards tumor cells. The
objective of the present study is to synthesize a new dioxime derivative to be labeled with …
objective of the present study is to synthesize a new dioxime derivative to be labeled with …
99mTc-amitrole as a novel selective imaging probe for solid tumor: in silico and preclinical pharmacological study
Lactoperoxidase (LPO) inhibitors are very selective for solid tumor due to their high binding
affinity to the LPO enzyme. A computational study was used to select top-ranked LPO …
affinity to the LPO enzyme. A computational study was used to select top-ranked LPO …
Contribution of both olfactory and systemic pathways for brain targeting of nimodipine-loaded lipo-pluronics micelles: in vitro characterization and in vivo …
Nimodipine (NM) is the only FDA-approved drug for treating subarachnoid hemorrhage
induced vasospasm. NM has poor oral bioavailability (5–13%) due to its low aqueous …
induced vasospasm. NM has poor oral bioavailability (5–13%) due to its low aqueous …
Synthesis, radiolabeling and biological distribution of a new dioxime derivative as a potential tumor imaging agent
MA Motaleb, AA Selim, M El-Tawoosy… - … of Radioanalytical and …, 2017 - Springer
A novel dioxime derivative (2 E, 2′ E, 3 E, 3′ E)-3, 3′-(pyrimidine-4, 5-diylbis
(azanylylidene)) bis (butan-2-one) dioxime was synthesized with a yield of 65%. IR …
(azanylylidene)) bis (butan-2-one) dioxime was synthesized with a yield of 65%. IR …
Platelet-12 lipoxygenase targeting via a newly synthesized curcumin derivative radiolabeled with technetium-99m
Background One of the most popular techniques for cancer detection is the nuclear
medicine technique. The present research focuses on Platelet-12-lipoxygenase (P-12-LOX) …
medicine technique. The present research focuses on Platelet-12-lipoxygenase (P-12-LOX) …
Design and synthesis of novel pyrazolo [3, 4-d] pyrimidin-4-one bearing quinoline scaffold as potent dual PDE5 inhibitors and apoptotic inducers for cancer therapy
PDE5 targeting represents a new and promising strategy for apoptosis induction and
inhibition of tumor cell growth due to its over-expression in diverse types of human …
inhibition of tumor cell growth due to its over-expression in diverse types of human …
Radiolabeling, Preparation, and Bioevaluation of 99mTc-Azathioprine as a Potential Targeting Agent for Solid Tumor Imaging
Azathioprine, an antitumor agent, was labeled with 99 m Tc using stannous chloride
dihydrate as a reducing agent. Factors such as the amounts of the reducing agent and …
dihydrate as a reducing agent. Factors such as the amounts of the reducing agent and …
Radioiodinated doxorubicin as a new tumor imaging model: preparation, biological evaluation, docking and molecular dynamics
AB Ibrahim, M Alaraby Salem, TW Fasih… - … of Radioanalytical and …, 2018 - Springer
Non-invasive molecular imaging techniques are accruing more interest in the last decades.
Several radiolabelling elements have been FDA-approved and are currently used to …
Several radiolabelling elements have been FDA-approved and are currently used to …