The goal of this review is to present a comprehensive survey of the many intriguing facets of
creatine (Cr) and creatinine metabolism, encompassing the pathways and regulation of Cr …

Mitochondrial creatine kinase (MtCK), together with cytosolic creatine kinase isoenzymes
and the highly diffusible CK reaction product, phosphocreatine, provide a temporal and …

Large amounts of energy are required to maintain the signaling activities of CNS cells.
Because of the fine-grained heterogeneity of brain and the rapid changes in energy …

Heart failure (HF) is a syndrome resulting from the inability of the cardiac pump to meet the
energy requirements of the body. Despite intensive work, the pathogenesis of the cardiac …

Background/Aims: We assessed mitochondrial morphology by electron microscopy and the
prevalence of a mitochondrial gene deletion in patients with nonalcoholic steatohepatitis …

Vandenberghe, K., M. Goris, P. Van Hecke, M. Van Leemputte, L. Vangerven, and P. Hespel.
Long-term creatine intake is beneficial to muscle performance during resistance training. J …

2.2. 2. Changes in intracellular ion concentrations 3. Energy parameters and changes
therein during increased activity, hypoglycemia and hypoxia/ischemia L 1. Alterations in …

▪ Abstract Phosphagens are phosphorylated guanidino compounds that are linked to energy
state and ATP hydrolysis by corresponding phosphagen kinase reactions: phosphagen+ …

Creatine kinase catalyses the reversible transphosphorylation of creatine by ATP. In the cell,
creatine kinase isoenzymes are specifically localized at strategic sites of ATP consumption …

Over the past years, a concept for creatine kinase function, the 'PCr-circuit'model, has
evolved. Based on this concept, multiple functions for the CK/PCr-system have been …