Skeletal muscles are essential for vital functions such as movement, postural support,
breathing, and thermogenesis. Muscle tissue is largely composed of long, postmitotic …

Skeletal muscle development and regeneration is governed by the combined action of Myf5,
MyoD, Mrf4 and MyoG, also known as the myogenic regulatory factors (MRFs). These …

Neat1 is widely expressed in many tissues and cells and exerts pro-proliferation effects on
many cancer cells. However, little is known about the function of Neat1 in myogenesis. Here …

Many microRNAs (miRNAs) are generated from primary transcripts containing multiple
clustered stem-loop structures that are thought to be recognized and cleaved by the …

Mammalian SWI/SNF (mSWI/SNF) complexes are ATP-dependent chromatin remodeling
enzymes that are critical for normal cellular functions. mSWI/SNF enzymes are classified into …

Background The AP-1 transcription factor, FBJ osteosarcoma oncogene (FOS), is induced in
adult muscle satellite cells (SCs) within hours following muscle damage and is required for …

Skeletal muscle regeneration in the adult (de novo myogenesis) depends on a resident
population of muscle stem cells (satellite cells) that are normally quiescent. In response to …

RNA-binding proteins play a central role in cellular metabolism by orchestrating the complex
interactions of coding, structural and regulatory RNA species. The SAFB (scaffold …

Disorganization of the basic contractile unit of muscle cells, ie, the sarcomeres, leads to
suboptimal force generation and is a hallmark of muscle atrophy. Here, we demonstrate that …

Cellular commitment and differentiation involve highly coordinated mechanisms by which
tissue-specific genes are activated while others are repressed. These mechanisms rely on …