As an essential component of the maternal-fetal interface, the placental syncytiotrophoblast
layer contributes to a successful pregnancy by secreting hormones necessary for …

Dietary polyunsaturated fatty acids (PUFAs), especially omega-3 (n-3) and n-6 long-chain
(LC) PUFAs, are indispensable for the fetus' brain supplied by the placenta. Despite being …

Epigenetics modification such as DNA methylation can affect maternal health during the
gestation period. Furthermore, pregnancy can drive a range of physiological and molecular …

Telomeres are nucleoprotein complexes located at the distal ends of chromosomes. In
adults, progressive telomere shortening occurs throughout the lifetime and is thought to …

Background The uterine environment may influence telomere length at birth, which is
essential for cellular function, aging, and disease susceptibility over the lifespan. However …

Placental microRNAs (miRNAs) regulate the placental transcriptome and play a pathological
role in preeclampsia (PE), a hypertensive disorder of pregnancy. Three PE rodent model …

Background Studies have recently examined the role of epigenetic mechanisms in
preeclampsia pathophysiology. One commonly examined epigenetic process is DNA …

Trophoblasts are specialized epithelial cells that perform critical functions during blastocyst
implantation and mediate maternal–fetal communication during pregnancy. However, our …

Telomere disorders have been associated with aging-related diseases, including diabetes,
vascular, and neurodegenerative diseases. The main consequence of altered telomere is …

Purpose To explore changes in telomere length (TL) and mitochondrial copy number
(mtDNA-CN) in preeclampsia (PE) and to evaluate the combined effect of maternal TL and …