Natural killer cell specificity for viral infections
Natural killer (NK) cells are lymphocytes that contribute to the early immune responses to
viruses. NK cells are innate immune cells that do not express rearranged antigen receptors …
viruses. NK cells are innate immune cells that do not express rearranged antigen receptors …
Control of human viral infections by natural killer cells
S Jost, M Altfeld - Annual review of immunology, 2013 - annualreviews.org
Natural killer (NK) cells are effector cells of the innate immune system and are important in
the control of viral infections. Their relevance is reflected by the multiple mechanisms …
the control of viral infections. Their relevance is reflected by the multiple mechanisms …
The dual role of HLA-C in tolerance and immunity at the maternal-fetal interface
H Papúchová, TB Meissner, Q Li… - Frontiers in …, 2019 - frontiersin.org
To establish a healthy pregnancy, maternal immune cells must tolerate fetal allo-antigens
and remain competent to respond to infections both systemically and in placental tissues …
and remain competent to respond to infections both systemically and in placental tissues …
Type I interferon protects antiviral CD8+ T cells from NK cell cytotoxicity
Despite development of new antiviral drugs, viral infections are still a major health problem.
The most potent antiviral defense mechanism is the innate production of type I interferon …
The most potent antiviral defense mechanism is the innate production of type I interferon …
Immunological analysis during interferon-free therapy for chronic hepatitis C virus infection reveals modulation of the natural killer cell compartment
M Spaan, G van Oord, K Kreefft, J Hou… - The Journal of …, 2016 - academic.oup.com
Background. Chronic hepatitis C virus (HCV) infection is a global health problem, resulting
in liver failure, hepatocellular carcinoma, and liver-related death. Natural killer (NK) cells are …
in liver failure, hepatocellular carcinoma, and liver-related death. Natural killer (NK) cells are …
A KIR B centromeric region present in Africans but not Europeans protects pregnant women from pre-eclampsia
A Nakimuli, O Chazara, SE Hiby… - Proceedings of the …, 2015 - National Acad Sciences
In sub-Saharan Africans, maternal mortality is unacceptably high, with> 400 deaths per
100,000 births compared with< 10 deaths per 100,000 births in Europeans. One-third of the …
100,000 births compared with< 10 deaths per 100,000 births in Europeans. One-third of the …
NK cells and interferons
R Paolini, G Bernardini, R Molfetta, A Santoni - Cytokine & growth factor …, 2015 - Elsevier
Abstract The role of Natural Killer cells in host defense against infections as well as in
tumour surveillance has been widely appreciated for a number of years. Upon recognition of …
tumour surveillance has been widely appreciated for a number of years. Upon recognition of …
Innate receptors with high specificity for HLA class I–peptide complexes
Genetic studies associate killer cell immunoglobulin-like receptors (KIRs) and their HLA
class I ligands with a variety of human diseases. The basis for these associations and the …
class I ligands with a variety of human diseases. The basis for these associations and the …
Failure of innate and adaptive immune responses in controlling hepatitis C virus infection
R Thimme, M Binder… - FEMS microbiology …, 2012 - academic.oup.com
Effective innate and adaptive immune responses are essential for the control of hepatitis C
virus (HCV) infection. Indeed, elimination of HCV during acute infection correlates with an …
virus (HCV) infection. Indeed, elimination of HCV during acute infection correlates with an …
Early changes in natural killer cell function indicate virologic response to interferon therapy for hepatitis C
BACKGROUND & AIMS: Mathematical modeling of hepatitis C virus (HCV) kinetics indicated
that cellular immune responses contribute to interferon (IFN)-induced clearance of HCV. We …
that cellular immune responses contribute to interferon (IFN)-induced clearance of HCV. We …