Advances in mass spectrometry imaging for spatial cancer metabolomics

X Ma, FM Fernández - Mass spectrometry reviews, 2024 - Wiley Online Library
Mass spectrometry (MS) has become a central technique in cancer research. The ability to
analyze various types of biomolecules in complex biological matrices makes it well suited for …

Mass spectrometry imaging for clinical research–latest developments, applications, and current limitations

PM Vaysse, RMA Heeren, T Porta, B Balluff - Analyst, 2017 - pubs.rsc.org
Mass spectrometry is being used in many clinical research areas ranging from toxicology to
personalized medicine. Of all the mass spectrometry techniques, mass spectrometry …

High-mass-resolution MALDI mass spectrometry imaging of metabolites from formalin-fixed paraffin-embedded tissue

A Ly, A Buck, B Balluff, N Sun, K Gorzolka… - Nature protocols, 2016 - nature.com
Formalin-fixed and paraffin-embedded (FFPE) tissue specimens are the gold standard for
histological examination, and they provide valuable molecular information in tissue-based …

Applications of fourier transform ion cyclotron resonance (FT-ICR) and orbitrap based high resolution mass spectrometry in metabolomics and lipidomics

M Ghaste, R Mistrik, V Shulaev - International journal of molecular …, 2016 - mdpi.com
Metabolomics, along with other “omics” approaches, is rapidly becoming one of the major
approaches aimed at understanding the organization and dynamics of metabolic networks …

A new update of MALDI-TOF mass spectrometry in lipid research

KM Engel, P Prabutzki, J Leopold, A Nimptsch… - Progress in lipid …, 2022 - Elsevier
Matrix-assisted laser desorption and ionization (MALDI) mass spectrometry (MS) is an
indispensable tool in modern lipid research since it is fast, sensitive, tolerates sample …

Metabolomics technology and bioinformatics for precision medicine

RK Azad, V Shulaev - Briefings in bioinformatics, 2019 - academic.oup.com
Precision medicine is rapidly emerging as a strategy to tailor medical treatment to a small
group or even individual patients based on their genetics, environment and lifestyle …

Adrenal tropism of SARS-CoV-2 and adrenal findings in a post-mortem case series of patients with severe fatal COVID-19

T Paul, S Ledderose, H Bartsch, N Sun… - Nature …, 2022 - nature.com
Progressive respiratory failure and hyperinflammatory response is the primary cause of
death in the coronavirus disease 2019 (COVID-19) pandemic. Despite mounting evidence of …

Spatial metabolomics identifies distinct tumor-specific subtypes in gastric cancer patients

J Wang, T Kunzke, VM Prade, J Shen, A Buck… - Clinical Cancer …, 2022 - AACR
Purpose: Current systems of gastric cancer molecular classification include genomic,
molecular, and morphological features. Gastric cancer classification based on tissue …

Spatial metabolomics for evaluating response to neoadjuvant therapy in non‐small cell lung cancer patients

J Shen, N Sun, P Zens, T Kunzke, A Buck… - Cancer …, 2022 - Wiley Online Library
Background The response to neoadjuvant chemotherapy (NAC) differs substantially among
individual patients with non‐small cell lung cancer (NSCLC). Major pathological response …

Hyperglycemia exacerbates colon cancer malignancy through hexosamine biosynthetic pathway

A Vasconcelos-Dos-Santos, H Loponte, NR Mantuano… - Oncogenesis, 2017 - nature.com
Hyperglycemia is a common feature of diabetes mellitus, considered as a risk factor for
cancer. However, its direct effects in cancer cell behavior are relatively unexplored. Herein …