Toxoplasma gondii infection and its implications within the central nervous system

SK Matta, N Rinkenberger, IR Dunay… - Nature Reviews …, 2021 - nature.com
Toxoplasma gondii is a parasite that infects a wide range of animals and causes zoonotic
infections in humans. Although it normally only results in mild illness in healthy individuals …

Lessons from Toxoplasma: Host responses that mediate parasite control and the microbial effectors that subvert them

EM Frickel, CA Hunter - Journal of Experimental Medicine, 2021 - rupress.org
The intracellular parasite Toxoplasma gondii has long provided a tractable experimental
system to investigate how the immune system deals with intracellular infections. This review …

[HTML][HTML] Neuroinflammation-associated aspecific manipulation of mouse predator fear by Toxoplasma gondii

M Boillat, PM Hammoudi, SK Dogga, S Pages… - Cell reports, 2020 - cell.com
In rodents, the decrease of felid aversion induced by Toxoplasma gondii, a phenomenon
termed fatal attraction, is interpreted as an adaptive manipulation by the neurotropic …

[HTML][HTML] The molecular biology and immune control of chronic Toxoplasma gondii infection

XY Zhao, SE Ewald - The Journal of clinical investigation, 2020 - Am Soc Clin Investig
Toxoplasma gondii is an incredibly successful parasite owing in part to its ability to persist
within cells for the life of the host. Remarkably, at least 350 host species of T. gondii have …

The pathogenicity and virulence of Toxoplasma gondii

SG Sanchez, S Besteiro - Virulence, 2021 - Taylor & Francis
Toxoplasma gondii is a parasitic protist infecting a wide group of warm-blooded animals,
ranging from birds to humans. While this infection is usually asymptomatic in healthy …

[HTML][HTML] A CRISPR platform for targeted in vivo screens identifies Toxoplasma gondii virulence factors in mice

J Young, C Dominicus, J Wagener… - Nature …, 2019 - nature.com
Genome-wide CRISPR screening is a powerful tool to identify genes required under
selective conditions. However, the inherent scale of genome-wide libraries can limit their …

[HTML][HTML] The Toxoplasma effector GRA28 promotes parasite dissemination by inducing dendritic cell-like migratory properties in infected macrophages

AL Ten Hoeve, L Braun, ME Rodriguez, GC Olivera… - Cell host & …, 2022 - cell.com
Upon pathogen detection, macrophages normally stay sessile in tissues while dendritic cells
(DCs) migrate to secondary lymphoid tissues. The obligate intracellular protozoan …

Dense granule biogenesis, secretion, and function in Toxoplasma gondii

MB Griffith, CS Pearce… - Journal of Eukaryotic …, 2022 - Wiley Online Library
Toxoplasma gondii is an obligate intracellular parasite and the causative agent of
Toxoplasmosis. A key to understanding and treating the disease lies with determining how …

[HTML][HTML] High-throughput identification of Toxoplasma gondii effector proteins that target host cell transcription

S Butterworth, K Kordova, S Chandrasekaran… - Cell Host & Microbe, 2023 - cell.com
Intracellular pathogens and other endosymbionts reprogram host cell transcription to
suppress immune responses and recalibrate biosynthetic pathways. This reprogramming is …

[HTML][HTML] Toxoplasma gondii secreted effectors co-opt host repressor complexes to inhibit necroptosis

A Rosenberg, LD Sibley - Cell host & microbe, 2021 - cell.com
Toxoplasma gondii translocates effector proteins into its host cell to subvert various host
pathways. T. gondii effector TgIST blocks the transcription of interferon-stimulated genes to …