The liver is the only solid organ that uses regenerative mechanisms to ensure that the liver-
to-bodyweight ratio is always at 100% of what is required for body homeostasis. Other solid …

Acetaminophen (N-acetyl-para-aminophenol; APAP) overdose is the most common cause of
acute liver failure in the Western world, with limited treatment opportunities. For years …

The hepatic mesenchyme has been studied extensively in the context of liver fibrosis;
however, much less is known regarding the role of mesenchymal cells during liver …

Conclusions ALI with therapeutic doses of APAP is associated with more severe liver injury
than overdose. It only occurs in patients with excess drinking and/or fasting. A warning …

Pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are two nuclear
receptors that are well-known for their roles in xenobiotic detoxification by regulating the …

The zonation of liver metabolic processes is well-characterized; however, little is known
about the cell type-specificity and zonation of sexually dimorphic gene expression or its …

Epidermal growth factor receptor (EGFR) is conventionally known to play a crucial role in
hepatocyte proliferation, liver regeneration and is also associated with hepatocellular …

Nuclear receptors (NRs), a superfamily of ligand-activated transcription factors, are critical in
cell growth, proliferation, differentiation, metabolism, and numerous biologic events. NRs …

The constitutive androstane receptor (CAR, NR3I1) belongs to nuclear receptor superfamily.
It was reported that CAR agonist TCPOBOP induces hepatomegaly but the underlying …

Dexamethasone (Dex), a widely prescribed anti-inflammatory drug, was reported to induce
liver enlargement (hepatomegaly) in clinical practice and in animal models. However, the …