Different animal models of pulmonary fibrosis have been developed to investigate potential
therapies for idiopathic pulmonary fibrosis (IPF). The most common is the bleomycin model …

Liver natural killer and natural killer T cells not only play a critical role in anti–viral and anti–
tumor defenses but also contribute to the pathogenesis of chronic liver diseases. Hepatic …

Rationale: Pulmonary hypertension (PH) is a common, severe comorbidity in interstitial lung
diseases such as pulmonary fibrosis (PF), and it has limited treatment options. Excessive …

Mice sc injected with bleomycin, an experimental model for human systemic sclerosis,
develop skin and lung fibrosis, which is mediated by inflammatory cell infiltration. This …

Background The failure of immune surveillance to remove senescent cells drives age-
related diseases. Here, we target an endogenous immune surveillance mechanism that can …

Objective The presence of anti–DNA topoisomerase I (anti–topo I) antibody correlates
positively with disease severity in patients with systemic sclerosis (SSc). However, the role of …

Chronic tissue inflammation often results in fibrosis characterized by the accumulation of
extracellular matrix components remodeling normal tissue architecture and function. Recent …

Mechanisms of chemoattraction underlie the spatial organization of the cells of the immune
system under basal conditions and the localization of these cells to sites of inflammation …

Pulmonary fibrosis is a progressive illness characterized by interstitial fibrosis. Although the
precise mechanism for pulmonary fibrosis is not completely understood, an immune …

It is widely accepted that inflammatory cells and cytokines play vital roles in the process of
pulmonary fibrosis. The aim of this study was to evaluate the preventative effects of …