[HTML][HTML] Inflammation and skeletal muscle wasting during cachexia
JM Webster, LJAP Kempen, RS Hardy… - Frontiers in …, 2020 - frontiersin.org
Cachexia is the involuntary loss of muscle and adipose tissue that strongly affects mortality
and treatment efficacy in patients with cancer or chronic inflammatory disease. Currently, no …
and treatment efficacy in patients with cancer or chronic inflammatory disease. Currently, no …
Pathophysiology of human visceral obesity: an update
A Tchernof, JP Després - Physiological reviews, 2013 - journals.physiology.org
Excess intra-abdominal adipose tissue accumulation, often termed visceral obesity, is part of
a phenotype including dysfunctional subcutaneous adipose tissue expansion and ectopic …
a phenotype including dysfunctional subcutaneous adipose tissue expansion and ectopic …
Mechanisms of glucocorticoid-induced insulin resistance: focus on adipose tissue function and lipid metabolism
EB Geer, J Islam, C Buettner - Endocrinology and Metabolism …, 2014 - endo.theclinics.com
Mechanisms of Glucocorticoid-Induced Insulin Resistance - Endocrinology and Metabolism
Clinics Skip to Main Content Skip to Main Menu Advertisement Endocrinology and …
Clinics Skip to Main Content Skip to Main Menu Advertisement Endocrinology and …
[HTML][HTML] Insulin and insulin resistance
G Wilcox - Clinical biochemist reviews, 2005 - ncbi.nlm.nih.gov
As obesity and diabetes reach epidemic proportions in the developed world, the role of
insulin resistance and its consequences are gaining prominence. Understanding the role of …
insulin resistance and its consequences are gaining prominence. Understanding the role of …
[HTML][HTML] Deconstructing the roles of glucocorticoids in adipose tissue biology and the development of central obesity
MJ Lee, P Pramyothin, K Karastergiou… - Biochimica et Biophysica …, 2014 - Elsevier
Central obesity is associated with insulin resistance and dyslipidemia. Thus, the
mechanisms that control fat distribution and its impact on systemic metabolism have …
mechanisms that control fat distribution and its impact on systemic metabolism have …
The pathogenetic role of cortisol in the metabolic syndrome: a hypothesis
Context: The metabolic syndrome (MetS) is a cluster of metabolic abnormalities that
increase the risk for type 2 diabetes mellitus and vascular disease. The common …
increase the risk for type 2 diabetes mellitus and vascular disease. The common …
11β-Hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response
JW Tomlinson, EA Walker, IJ Bujalska… - Endocrine …, 2004 - academic.oup.com
11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) interconverts inactive cortisone and
active cortisol. Although bidirectional, in vivo it is believed to function as a reductase …
active cortisol. Although bidirectional, in vivo it is believed to function as a reductase …
11β-HSD1 is the major regulator of the tissue-specific effects of circulating glucocorticoid excess
SA Morgan, EL McCabe… - Proceedings of the …, 2014 - National Acad Sciences
The adverse metabolic effects of prescribed and endogenous glucocorticoid (GC) excess,
Cushing syndrome, create a significant health burden. We found that tissue regeneration of …
Cushing syndrome, create a significant health burden. We found that tissue regeneration of …
Novel insights into glucocorticoid‐mediated diabetogenic effects: towards expansion of therapeutic options?
DH Van Raalte, DM Ouwens… - European journal of …, 2009 - Wiley Online Library
At pharmacological concentrations, glucocorticoids (GCs) display potent anti‐inflammatory
effects, and are therefore frequently prescribed by physicians to treat a wide variety of …
effects, and are therefore frequently prescribed by physicians to treat a wide variety of …
Stress and obesity: the role of the hypothalamic–pituitary–adrenal axis in metabolic disease
M Bose, B Oliván, B Laferrère - Current Opinion in Endocrinology …, 2009 - journals.lww.com
The present review provides evidence for the relationship between chronic stress,
alterations in HPA activity, and obesity. Understanding these associations and its …
alterations in HPA activity, and obesity. Understanding these associations and its …