Cachexia is the involuntary loss of muscle and adipose tissue that strongly affects mortality
and treatment efficacy in patients with cancer or chronic inflammatory disease. Currently, no …

Excess intra-abdominal adipose tissue accumulation, often termed visceral obesity, is part of
a phenotype including dysfunctional subcutaneous adipose tissue expansion and ectopic …

Mechanisms of Glucocorticoid-Induced Insulin Resistance - Endocrinology and Metabolism
Clinics Skip to Main Content Skip to Main Menu Advertisement Endocrinology and …

As obesity and diabetes reach epidemic proportions in the developed world, the role of
insulin resistance and its consequences are gaining prominence. Understanding the role of …

Central obesity is associated with insulin resistance and dyslipidemia. Thus, the
mechanisms that control fat distribution and its impact on systemic metabolism have …

Context: The metabolic syndrome (MetS) is a cluster of metabolic abnormalities that
increase the risk for type 2 diabetes mellitus and vascular disease. The common …

11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) interconverts inactive cortisone and
active cortisol. Although bidirectional, in vivo it is believed to function as a reductase …

The adverse metabolic effects of prescribed and endogenous glucocorticoid (GC) excess,
Cushing syndrome, create a significant health burden. We found that tissue regeneration of …

At pharmacological concentrations, glucocorticoids (GCs) display potent anti‐inflammatory
effects, and are therefore frequently prescribed by physicians to treat a wide variety of …

The present review provides evidence for the relationship between chronic stress,
alterations in HPA activity, and obesity. Understanding these associations and its …