Bruton's tyrosine kinase (BTK) is an essential component of multiple signaling pathways that
regulate B cell and myeloid cell proliferation, survival, and functions, making it a promising …

B cell receptor (BCR) signalling is crucial for normal B cell development and adaptive
immunity. BCR signalling also supports the survival and growth of malignant B cells in …

Signalling through the B cell receptor (BCR) is central to the development and maintenance
of B cells. In light of the numerous proliferative and survival pathways activated downstream …

Mounting evidence indicates that grouping of chronic lymphocytic leukemia (CLL) into
distinct subsets with stereotyped BCRs is functionally and prognostically relevant. However …

Chronic lymphocytic leukaemia (CLL) is the most common leukaemia among the adults in
the Western World. CLL (and the corresponding nodal entity small lymphocytic lymphoma …

The mechanisms that drive normal B cell differentiation and activation are frequently
subverted by B cell lymphomas for their unlimited growth and survival. B cells are …

Chronic lymphocytic leukaemia (CLL) has several unique features that distinguish it from
other cancers. Most CLL tumour cells are inert and arrested in G0/G1 of the cell cycle and …

The physiology of B cells is intimately connected with the function of their B‐cell receptor
(BCR). B‐cell lymphomas frequently (dys) regulate BCR signalling and thus take advantage …

Over the last decade, the active role of the microenvironment in the pathogenesis of B cell
lymphomas has been recognized, delivering signals that favor clonal expansion and drug …

The cellular origin of chronic lymphocytic leukemia (CLL) is still debated, although this
information is critical to understanding its pathogenesis. Transcriptome analyses of CLL and …