The uptake of calcium into and extrusion of calcium from the mitochondrial matrix is a
fundamental biological process that has critical effects on cellular metabolism, signaling …

The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …

In the heart, augmented Ca 2+ fluxing drives contractility and ATP generation through
mitochondrial Ca 2+ loading. Pathologic mitochondrial Ca 2+ overload with ischemic injury …

Background: Fundc1 (FUN14 domain containing 1), an outer mitochondrial membrane
protein, is important for mitophagy and mitochondria-associated endoplasmic reticulum …

Cancer cells have an abnormally high mitochondrial membrane potential (ΔΨm), which is
associated with enhanced invasive properties in vitro and increased metastases in vivo. The …

Phytosterols, which are derived from plants, have various beneficial physiological effects,
including anti-hypercholesterolemic, anti-inflammatory, and antifungal activities. The …

We provide a comprehensive review of the role of β-hydroxybutyrate (β-OHB), its linear
polymer poly-β-hydroxybutyrate (PHB), and inorganic polyphosphate (polyP) in mammalian …

Mitochondria capture and subsequently release Ca 2+ ions, thereby sensing and shaping
cellular Ca 2+ signals. The Ca 2+ uniporter MCU mediates Ca 2+ uptake, whereas NCLX …

In pancreatic β-cells, uptake of Ca 2+ into mitochondria facilitates metabolism-secretion
coupling by activation of various matrix enzymes, thus facilitating ATP generation by …

Mitochondrial Ca2+ overload can mediate mitochondria-dependent cell death, a major
contributor to several human diseases. Indeed, Duchenne muscular dystrophy (MD) is …