Variation in the mutation rate across mammalian genomes
A Hodgkinson, A Eyre-Walker - Nature reviews genetics, 2011 - nature.com
It has been known for many years that the mutation rate varies across the genome. However,
only with the advent of large genomic data sets is the full extent of this variation becoming …
only with the advent of large genomic data sets is the full extent of this variation becoming …
Direct and indirect consequences of meiotic recombination: implications for genome evolution
MT Webster, LD Hurst - Trends in genetics, 2012 - cell.com
There is considerable variation within eukaryotic genomes in the local rate of crossing over.
Why is this and what effect does it have on genome evolution? On the genome scale, it is …
Why is this and what effect does it have on genome evolution? On the genome scale, it is …
Accurate de novo and transmitted indel detection in exome-capture data using microassembly
We present an open-source algorithm, Scalpel (http://scalpel. sourceforge. net/), which
combines mapping and assembly for sensitive and specific discovery of insertions and …
combines mapping and assembly for sensitive and specific discovery of insertions and …
Pattern and variation in simple sequence repeat (SSR) at different genomic regions and its implications to maize evolution and breeding
M Zhao, G Shu, Y Hu, G Cao, Y Wang - BMC genomics, 2023 - Springer
Background Repetitive DNA sequences accounts for over 80% of maize genome. Although
simple sequence repeats (SSRs) account for only 0.03% of the genome, they have been …
simple sequence repeats (SSRs) account for only 0.03% of the genome, they have been …
Genome-wide selection signatures address trait specific candidate genes in cattle indigenous to arid regions of India
The peculiarity of Indian cattle lies in milk quality, resistance to diseases and stressors as
well as adaptability. The investigation addressed selection signatures in Gir and Tharparkar …
well as adaptability. The investigation addressed selection signatures in Gir and Tharparkar …
On the sequence‐directed nature of human gene mutation: the role of genomic architecture and the local DNA sequence environment in mediating gene mutations …
Different types of human gene mutation may vary in size, from structural variants (SVs) to
single base‐pair substitutions, but what they all have in common is that their nature, size and …
single base‐pair substitutions, but what they all have in common is that their nature, size and …
Genetic etiology of truncus arteriosus excluding 22q11.2 deletion syndrome and identification of c.1617del, a prevalent variant in TMEM260, in the Japanese …
H Yaoita, E Kawai, J Takayama, S Iwasawa… - Journal of Human …, 2024 - nature.com
Truncus Arteriosus (TA) is a congenital heart disease characterized by a single common
blood vessel emerging from the right and left ventricles instead of the main pulmonary artery …
blood vessel emerging from the right and left ventricles instead of the main pulmonary artery …
IntSIM: an integrated simulator of next-generation sequencing data
X Yuan, J Zhang, L Yang - IEEE Transactions on Biomedical …, 2016 - ieeexplore.ieee.org
Objective: Next-generation sequencing data has been widely used for DNA variant
discovery and tumor study through computational tools. Effective simulation of such data …
discovery and tumor study through computational tools. Effective simulation of such data …
Recombination drives vertebrate genome contraction
K Nam, H Ellegren - PLoS genetics, 2012 - journals.plos.org
Selective and/or neutral processes may govern variation in DNA content and, ultimately,
genome size. The observation in several organisms of a negative correlation between …
genome size. The observation in several organisms of a negative correlation between …
[PDF][PDF] InDel 标记的研究和应用进展
杨洁， 赫佳， 王丹碧， 施恩， 杨文宇， 耿其芳， 王中生 - 生物多样性, 2016 - plant-ecology.com
InDel 是指在近缘种或同一物种不同个体之间基因组同一位点的序列发生不同大小核苷酸片段的
插入或缺失(insertion-deletion), 是同源序列比对产生空位(gap) 的现象. InDel …
插入或缺失(insertion-deletion), 是同源序列比对产生空位(gap) 的现象. InDel …