Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …

Hydrogen sulfide (H 2 S) is now recognized as an endogenous signaling gasotransmitter in
mammals. It is produced by mammalian cells and tissues by various enzymes …

Abstract Background Hydrogen sulfide (H 2 S), a gaseous signaling molecule that impacts
multiple physiological processes including aging, is produced via select mammalian …

Introduction Alpha-lipoic acid (ALA) is a licensed drug for the treatment of diabetic
neuropathy. We recently reported that it also improves diabetic cardiomyopathy (DCM) in …

Introduction We previously reported that alpha-lipoic acid (ALA) supplementation protects
against progression of diabetic kidney disease (DKD). In this study, we aim to investigate …

Cold ischemia-reperfusion injury (IRI) is an inevitable and unresolved problem that poses a
great challenge in solid organ transplantation (SOT). It represents a major factor that …

There are over 8 million species in this world that live in widely varying environments, from
hot thermal fissures to cold arctic settings. These species have evolved over millions of …

Disorders characterized by ischemia/reperfusion (I/R) are the most common causes of
debilitating diseases and death in stroke, cardiovascular ischemia, acute kidney injury or …

Background Since the start of organ transplantation, hypothermia-forced hypometabolism
has been the cornerstone in organ preservation. Cold preservation showed to protect …

The use of blood for normothermic and subnormothermic kidney preservation hinders the
translation of these approaches and promising therapeutics. This study evaluates whether …