The predominant focus in the neurobiological study of memory has been on remembering
(persistence). However, recent studies have considered the neurobiology of forgetting …

Pioneering research studies, beginning with those using Drosophila, have identified several
molecular and cellular mechanisms for active forgetting. The currently known mechanisms …

A new theory about the origins of consciousness that finds learning to be the driving force in
the evolutionary transition to basic consciousness. What marked the evolutionary transition …

Dendritic spines are small protrusive structures on dendritic surfaces, and function as
postsynaptic compartments for excitatory synapses. Plasticity of spine structure is associated …

Posttranscriptional gene expression including splicing, RNA transport, translation, and RNA
decay provides an important regulatory layer in many if not all molecular pathways …

The neurobiological processes underpinning the natural forgetting of long-term memories
are poorly understood. Based on the critical role of GluA2-containing AMPA receptors …

Evidence indicates that long-term memory formation involves alterations in synaptic efficacy
produced by modifications in neural transmission and morphology. However, it is not clear …

Animals with complex nervous systems demand sleep for memory consolidation and
synaptic remodeling. Here, we show that, although the Caenorhabditis elegans nervous …

The brain has a remarkable but underappreciated capacity to limit memory formation and
expression. The term" memory suppressor gene" was coined in 1998 as an attempt to …

Polarization of cells into a protrusive front and a retracting cell body is the hallmark of
mesenchymal-like cell migration. Many mRNAs are localized to protrusions, but it is unclear …