Immune memory is tailored by cues that lymphocytes perceive during priming. The severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic created a situation in …

Neutrophils are increasingly recognized as key players in the tumor immune response and
are associated with poor clinical outcomes. Despite recent advances characterizing the …

Single-cell proteomics is a promising field to provide direct yet comprehensive molecular
insights into cellular functions without averaging effects. Here, we address a grand technical …

Tumor-associated macrophages (TAMs) are a heterogeneous population of cells whose
phenotypes and functions are shaped by factors that are incompletely understood. Herein …

Memory CD8+ T cells can be broadly divided into circulating (T CIRCM) and tissue-resident
memory T (T RM) populations. Despite well-defined migratory and transcriptional …

Myeloid cells represent a dominant cellular compartment of tumor lesions and play key roles
in tumor inception, progression, metastasis, and response to treatment. Mononuclear …

Plasmacytoid dendritic cells (pDCs) have been shown to play an important role during
immune responses, ranging from initial viral control through the production of type I …

Inflammatory stimuli cause a state of emergency myelopoiesis leading to neutrophil-like
monocyte expansion. However, their function, the committed precursors, or growth factors …

Abstract Analysis of the human hematopoietic progenitor compartment is being transformed
by single-cell multimodal approaches. Cellular indexing of transcriptomes and epitopes by …

The thymus medulla is a key site for immunoregulation and tolerance, and its functional
specialisation is achieved through the complexity of medullary thymic epithelial cells …