Viral evolution impacts diagnostic test performance through the emergence of variants with
sequences affecting the efficiency of primer binding. Such variants that evade detection by …

Nucleoside analogs are a major class of antiviral drugs. Some act by increasing the viral
mutation rate causing lethal mutagenesis of the virus. Their mutagenic capacity, however …

Rationale Although COVID-19 is predominantly a respiratory tract infection, current antibody
treatments are administered by systemic dosing. We hypothesize that inhaled delivery of a …

Background: There is little data about the performance of multiplex rapid antigen tests
(RATs) on the detection of SARS-CoV-2, influenza A (Flu A), and influenza B (Flu B). This …

Background Effective isolation and early treatment of coronavirus disease 2019 (COVID-19)
relies on rapid, accurate, and straightforward diagnostic tools. In response to the rapidly …

Objectives: We compared the viral cycle threshold (Ct) value of infected patients to better
understand the viral kinetics during the dominant period in which a specific virus type …

OBJECTIVES We compared the viral cycle threshold (Ct) values of infected patients to better
understand viral kinetics by vaccination status during different periods of variant …

The impact of nasal obstruction on sleep and on patients with obstructive sleep apnoea
(OSA) is still a matter of great debate. This might be related to the conflicting evidence of …

Study design Saliva has been proposed as valid alternative for nasopharyngeal swab for RT-
qPCR detection of SARS-CoV-2. The sensitivity is generally equivalent, and it comes with …

This chapter will consider the viral pathogen that has left an indelible mark on our lives and
our world and look at the evidence for how it causes its pathophysiology inside the nose …