A major function of the mitogen-activated protein kinase (MAPK) pathways is to control
eukaryotic gene expression programmes in response to extracellular signals. MAPKs …

The mitogen-activated protein kinases (MAPKs) are a family of serine/threonine kinases that
play an essential role in signal transduction by modulating gene transcription in the nucleus …

Type 2 diabetes (T2DM) commonly arises from islet β cell failure and insulin resistance.
Here, we examined the sensitivity of key islet-enriched transcription factors to oxidative …

Of the three critical enhancer elements that mediate β-cell-specific and glucose-responsive
expression of the insulin gene, only the identity of the transcription factor binding to the …

The insulin gene is specifically expressed in β-cells of the Langerhans islets of the
pancreas, and its transcription is regulated by the circulating glucose level. Previous reports …

Abstract The C1/RIPE3b1 (− 118/− 107 bp) binding factor regulates pancreatic-β-cell-
specific and glucose-regulated transcription of the insulin gene. In the present study, the …

Like JUN and FOS, the Maf transcription factors belong to the AP1 family. Besides their
established role in human cancer—overexpression of the large Maf genes promotes the …

Production and secretion of insulin from the β-cells of the pancreas is very crucial in
maintaining normoglycaemia. This is achieved by tight regulation of insulin synthesis and …

The islet-enriched MafA, PDX-1, and BETA2 activators contribute to both β cell-specific and
glucose-responsive insulin gene transcription. To investigate how these factors impart …

Recent studies demonstrated a number of links between chromatin structure, gene
expression, extracellular signaling and cellular differentiation during lens development …