Nitric oxide (NO) is an important vasodilator with a well-established role in cardiovascular
homeostasis. While mediator is synthesized from L-arginine by neuronal, endothelial, and …

Introduction The association between ischemic stroke and genetic polymorphisms of
methylenetetrahydrofolate reductase (MTHFR; 677C> T and 1298A> C), endothelial nitric …

Nitric oxide (NO) is a vasoactive substance synthesized from l-arginine by neuronal (NOS1),
endothelial (NOS3), and inducible (NOS2) nitric oxide synthases. NOS3 is the most …

Statins exert anti-inflammatory effects and downregulate matrix metalloproteinases (MMPs)
expression, thus contributing to restore cardiovascular homeostasis in cardiovascular …

Purpose The antihypertensive effect of angiotensin-converting enzyme inhibitors (ACEi) is
attributed partially to increased nitric oxide bioavailability. It is possible that functional …

Arginase 1 and Arginase 2 are homologous enzymes that convert l-Arginine to Urea and l-
ornithine and compete with nitric oxide synthases for l-Arginine. Increased Arginase 1 and 2 …

Introduction Nitric oxide (NO) is a molecule with multiple functions. Several drugs involve the
modulation of NO levels in their mechanism of action. NO is mainly produced in vessels by …

We investigated whether genetic polymorphisms in the endothelial nitric oxide (eNOS) gene
(T 786 C in the promoter region, Glu298Asp in exon 7, and 4b/4a in intron 4) or eNOS …

Endothelial nitric oxide synthase (NOS3 or eNOS) is the enzyme responsible for the highest
production of nitric oxide, with the greatest impact on the cardiovascular system, encoded by …

Endothelial nitric oxide synthase (NOS3) is a key enzyme responsible for nitric oxide (NO)
generation in the vascular endothelium. Endothelial dysfunction is characterized by reduced …