Chemical design of activatable photoacoustic probes for precise biomedical applications

Y Liu, L Teng, B Yin, H Meng, X Yin, S Huan… - Chemical …, 2022 - ACS Publications
Photoacoustic (PA) imaging technology, a three-dimensional hybrid imaging modality that
integrates the advantage of optical and acoustic imaging, has great application prospects in …

Novel pharmacological approaches in abdominal aortic aneurysm

L Puertas-Umbert, R Almendra-Pegueros… - Clinical …, 2023 - portlandpress.com
Abdominal aortic aneurysm (AAA) is a severe vascular disease and a major public health
issue with an unmet medical need for therapy. This disease is featured by a progressive …

From traditional pharmacological towards nucleic acid-based therapies for cardiovascular diseases

U Landmesser, W Poller, S Tsimikas… - European heart …, 2020 - academic.oup.com
Nucleic acid-based therapeutics are currently developed at large scale for prevention and
management of cardiovascular diseases (CVDs), since:(i) genetic studies have highlighted …

DNA methylation in the pathogenesis of polycystic ovary syndrome

ER Vázquez-Martínez, YI Gómez-Viais… - …, 2019 - rep.bioscientifica.com
Polycystic ovary syndrome (PCOS) is the leading endocrine and metabolic disorder in
premenopausal women characterized by hyperandrogenism and abnormal development of …

Function of histone methylation and acetylation modifiers in cardiac hypertrophy

J Qin, N Guo, J Tong, Z Wang - Journal of molecular and cellular cardiology, 2021 - Elsevier
Cardiac hypertrophy is an adaptive response of the heart to increased workload induced by
various physiological or pathological stimuli. It is a common pathological process in multiple …

A novel role for vaping in mitochondrial gene dysregulation and inflammation fundamental to disease development

S Tommasi, N Pabustan, M Li, Y Chen, KD Siegmund… - Scientific reports, 2021 - nature.com
We constructed and analyzed the whole transcriptome in leukocytes of healthy adult vapers
(with/without a history of smoking),'exclusive'cigarette smokers, and controls (non-users of …

Platelet mitochondrial DNA methylation predicts future cardiovascular outcome in adults with overweight and obesity

S Corsi, S Iodice, L Vigna, A Cayir, JC Mathers… - Clinical …, 2020 - Springer
Background The association between obesity and cardiovascular disease (CVD) is proven,
but why some adults with obesity develop CVD while others remain disease-free is poorly …

Early-life nutrition and metabolic disorders in later life: A new perspective on energy metabolism

LY Zhou, MQ Deng, Q Zhang, XH Xiao - Chinese medical journal, 2020 - mednexus.org
Type 2 diabetes mellitus and metabolic disorders have become an epidemic globally.
However, the pathogenesis remains largely unclear and the prevention and treatment are …

[HTML][HTML] Epigenetics and microRNAs in cardiovascular diseases

RMW Colpaert, M Calore - Genomics, 2021 - Elsevier
Cardiovascular diseases are among the leading causes of mortality worldwide. Besides
environmental and genetic changes, these disorders can be influenced by processes which …

Epigenome-wide analysis of DNA methylation and coronary heart disease: a nested case-control study

J Si, S Yang, D Sun, C Yu, Y Guo, Y Lin, IY Millwood… - Elife, 2021 - elifesciences.org
Background: Identifying environmentally responsive genetic loci where DNA methylation is
associated with coronary heart disease (CHD) may reveal novel pathways or therapeutic …