Tracking neuroinflammatory biomarkers in Alzheimer's disease: a strategy for individualized therapeutic approaches?
S Lista, BP Imbimbo, M Grasso, A Fidilio… - Journal of …, 2024 - Springer
Background Recent trials of anti-amyloid-β (Aβ) monoclonal antibodies, including
lecanemab and donanemab, in early Alzheimer disease (AD) showed that these drugs have …
lecanemab and donanemab, in early Alzheimer disease (AD) showed that these drugs have …
A critical appraisal of blood-based biomarkers for Alzheimer's disease
Biomarkers that predict the clinical onset of Alzheimer's disease (AD) enable the
identification of individuals in the early, preclinical stages of the disease. Detecting AD at this …
identification of individuals in the early, preclinical stages of the disease. Detecting AD at this …
A neuroimaging biomarker for Individual Brain-Related Abnormalities In Neurodegeneration (IBRAIN): a cross-sectional study
Background Alzheimer's disease (AD) is a prevalent neurodegenerative disorder that poses
a worldwide public health challenge. A neuroimaging biomarker would significantly improve …
a worldwide public health challenge. A neuroimaging biomarker would significantly improve …
CSF and blood glial fibrillary acidic protein for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis
Y Zou, Y Wang, X Ma, D Mu, J Zhong, C Ma… - Ageing Research …, 2024 - Elsevier
Recently included in the 2024 new revised diagnostic criteria of Alzheimer's disease (AD),
glial fibrillary acidic protein (GFAP) has garnered significant attention. A systematic review …
glial fibrillary acidic protein (GFAP) has garnered significant attention. A systematic review …
Plasma biomarkers of Alzheimer's disease and neurodegeneration according to sociodemographic characteristics and chronic health conditions
Ultrasensitive assays have been developed which enable biomarkers of Alzheimer's
disease pathology and neurodegeneration to be measured in blood. These biomarkers can …
disease pathology and neurodegeneration to be measured in blood. These biomarkers can …
Changes in Alzheimer disease blood biomarkers and associations with incident all-cause dementia
Y Lu, JR Pike, J Chen, KA Walker, KJ Sullivan… - JAMA, 2024 - jamanetwork.com
Importance Plasma biomarkers show promise for identifying Alzheimer disease (AD)
neuropathology and neurodegeneration, but additional examination among diverse …
neuropathology and neurodegeneration, but additional examination among diverse …
A Statistical Framework for Assessing the Relationship between Biomarkers and Clinical Endpoints in Alzheimer's Disease
Abstract Changes in biomarker levels of Alzheimer's disease (AD) reflect underlying
pathophysiological changes in the brain and can provide evidence of direct and …
pathophysiological changes in the brain and can provide evidence of direct and …
Performance of SOBA-AD blood test in discriminating Alzheimer's disease patients from cognitively unimpaired controls in two independent cohorts
A Chen, D Shea, V Daggett - Scientific Reports, 2024 - nature.com
Amyloid-beta (Aβ) toxic oligomers are critical early players in the molecular pathology of
Alzheimer's disease (AD). We have developed a Soluble Oligomer Binding Assay (SOBA …
Alzheimer's disease (AD). We have developed a Soluble Oligomer Binding Assay (SOBA …
Precuneus activity during retrieval is positively associated with amyloid burden in cognitively normal older APOE4 carriers
L Fischer, EN Molloy, A Pichet Binette, N Vockert… - bioRxiv, 2024 - biorxiv.org
The precuneus is an early site of amyloid-beta accumulation. Previous cross-sectional
studies reported increased precuneus fMRI activity in older adults with mild cognitive deficits …
studies reported increased precuneus fMRI activity in older adults with mild cognitive deficits …
Risk of Alzheimer's disease is associated with longitudinal changes in plasma biomarkers in the multi‐ethnic Washington Heights–Hamilton Heights–Inwood …
BACKGROUND Alzheimer's disease (AD) biomarkers can help differentiate cognitively
unimpaired (CU) individuals from mild cognitive impairment (MCI) and dementia. The role of …
unimpaired (CU) individuals from mild cognitive impairment (MCI) and dementia. The role of …