The field of cAMP signaling is witnessing exciting developments with the recognition that
cAMP is compartmentalized and that spatial regulation of cAMP is critical for faithful signal …

Cellular signal transmission requires the dynamic formation of spatiotemporally controlled
molecular interactions. At the cell surface information is received by receptor complexes and …

Many of the fundamental concepts of signal transduction and kinase activity are attributed to
the discovery and crystallization of cAMP-dependent protein kinase, or protein kinase A …

Cyclic AMP (cAMP) plays a key regulatory role in most types of cells; however, the pathways
controlled by cAMP may present important differences between organisms and between …

The massed-spaced effect is a hallmark feature of memory formation. We now demonstrate
this effect in two separate non-neural, immortalized cell lines stably expressing a short-lived …

Human glioblastoma is the most frequent and aggressive form of brain tumour in the adult
population. Proteolytic turnover of tumour suppressors by the ubiquitin–proteasome system …

Extracellular signal-regulated kinase (ERK) and protein kinase A (PKA) play important roles
in LTP and spine structural plasticity. While fluorescence resonance energy transfer (FRET) …

Scaffolding proteins organize the information flow from activated G protein-coupled
receptors (GPCRs) to intracellular effector cascades both spatially and temporally. By this …

In the past decades, the Hippo signaling pathway has been delineated and shown to play
multiple roles in the control of organ size in both Drosophila and mammals. In mammals, the …

Abstract The 3′, 5′-cyclic adenosine monophosphate (cAMP) dependent protein kinase
(PKA) is a tetrameric holoenzyme comprising a set of two regulatory subunits (PKA-R) and …