Nanotechnological strategies for engineering complex tissues

T Dvir, BP Timko, DS Kohane… - Nano-Enabled Medical …, 2020 - taylorfrancis.com
Advances in nanotechnology provided the basis for fabrication of nanoparticulate delivery
systems with large ratios of surface area to volume, rendering them very effective within the …

Synthesis, properties and biomedical applications of poly (glycerol sebacate)(PGS): A review

R Rai, M Tallawi, A Grigore, AR Boccaccini - Progress in polymer science, 2012 - Elsevier
Poly (glycerol sebacate)(PGS) is a biodegradable polymer increasingly used in a variety of
biomedical applications. This polyester is prepared by polycondensation of glycerol and …

Nanowired three-dimensional cardiac patches

T Dvir, BP Timko, MD Brigham, SR Naik… - Nature …, 2011 - nature.com
Engineered cardiac patches for treating damaged heart tissues after a heart attack are
normally produced by seeding heart cells within three-dimensional porous biomaterial …

A self-healing, all-organic, conducting, composite peptide hydrogel as pressure sensor and electrogenic cell soft substrate

P Chakraborty, T Guterman, N Adadi, M Yadid… - ACS …, 2018 - ACS Publications
Conducting polymer hydrogels (CPHs) emerge as excellent functional materials, as they
harness the advantages of conducting polymers with the mechanical properties and …

Accordion-like honeycombs for tissue engineering of cardiac anisotropy

GC Engelmayr Jr, M Cheng, CJ Bettinger… - Nature materials, 2008 - nature.com
Tissue-engineered grafts may be useful in myocardial repair; however, previous scaffolds
have been structurally incompatible with recapitulating cardiac anisotropy. Here, we use …

Challenges in cardiac tissue engineering

G Vunjak-Novakovic, N Tandon, A Godier… - … Engineering Part B …, 2010 - liebertpub.com
Cardiac tissue engineering aims to create functional tissue constructs that can reestablish
the structure and function of injured myocardium. Engineered constructs can also serve as …

Dynamic culture yields engineered myocardium with near-adult functional output

CP Jackman, AL Carlson, N Bursac - Biomaterials, 2016 - Elsevier
Engineered cardiac tissues hold promise for cell therapy and drug development, but exhibit
inadequate function and maturity. In this study, we sought to significantly improve the …

Prevascularization of cardiac patch on the omentum improves its therapeutic outcome

T Dvir, A Kedem, E Ruvinov, O Levy… - Proceedings of the …, 2009 - National Acad Sciences
The recent progress made in the bioengineering of cardiac patches offers a new therapeutic
modality for regenerating the myocardium after myocardial infarction (MI). We present here a …

Magnetic Nanoparticle-Based Approaches to Locally Target Therapy and Enhance Tissue Regeneration In Vivo

R Sensenig, Y Sapir, C MacDonald, S Cohen… - …, 2012 - Taylor & Francis
Magnetic-based systems utilizing superparamagnetic nanoparticles and a magnetic field
gradient to exert a force on these particles have been used in a wide range of biomedical …

The promotion of myocardial repair by the sequential delivery of IGF-1 and HGF from an injectable alginate biomaterial in a model of acute myocardial infarction

E Ruvinov, J Leor, S Cohen - Biomaterials, 2011 - Elsevier
Proper spatio-temporal delivery of multiple therapeutic proteins represents a major
challenge in therapy strategies aimed at inducing myocardial regeneration after myocardial …