[HTML][HTML] Challenges and opportunities of therapies targeting early life immunity for pediatric HIV cure

SJ Berendam, AN Nelson, B Yagnik… - Frontiers in …, 2022 - frontiersin.org
Early initiation of antiretroviral therapy (ART) significantly improves clinical outcomes and
reduces mortality of infants/children living with HIV. However, the ability of infected cells to …

[HTML][HTML] More than the Infinite Monkey Theorem: NHP Models in the Development of a Pediatric HIV Cure

JA Fonseca, AC King, A Chahroudi - Current HIV/AIDS Reports, 2024 - Springer
Abstract Purpose of Review An HIV cure that eliminates the viral reservoir or provides viral
control without antiretroviral therapy (ART) is an urgent need in children as they face unique …

Evolution of the gut microbiome in HIV-exposed uninfected and unexposed infants during the first year of life

CL Jackson, DN Frank, CE Robertson, D Ir… - Mbio, 2022 - Am Soc Microbiol
ABSTRACT HIV-exposed uninfected infants (HEU) have abnormal immunologic functions
and increased infectious morbidity in the first 6 months of life, which gradually decreases …

[HTML][HTML] Premature skewing of T cell receptor clonality and delayed memory expansion in HIV-exposed infants

S Dzanibe, AJ Wilk, S Canny, T Ranganath… - Nature …, 2024 - nature.com
While preventing vertical HIV transmission has been very successful, HIV-exposed
uninfected infants (iHEU) experience an elevated risk to infections compared to HIV …

Lower academic performance among children with perinatal HIV exposure in Botswana

KM Powis, L Lebanna, S Schenkel… - Journal of the …, 2023 - Wiley Online Library
Introduction Studies have reported a higher risk of suboptimal neurodevelopment among
children who are HIV‐exposed uninfected (HEU) compared to children HIV‐unexposed …

Viral Persistence in the Gut-Associated Lymphoid Tissue and Barriers to HIV Cure

F Cossarini, JA Aberg, BK Chen… - AIDS Research and …, 2024 - liebertpub.com
More than 40 years after the first reported cases of what then became known as acquired
immunodeficiency syndrome (AIDS), tremendous progress has been achieved in …

[HTML][HTML] Disrupted memory T cell expansion in HIV-exposed uninfected infants is preceded by premature skewing of T cell receptor clonality

S Dzanibe, AJ Wilk, S Canny, T Ranganath, B Alinde… - bioRxiv, 2023 - ncbi.nlm.nih.gov
While preventing vertical HIV transmission has been very successful, the increasing number
of HIV-exposed uninfected infants (iHEU) experience an elevated risk to infections …

Investigating the susceptibility of foreskin myeloid cells to ex vivo HIV infection

B Nleya - 2023 - open.uct.ac.za
Background: HIV/AIDS remains a global concern that, although manageable using anti-
retroviral therapy (ART), is still eluded by a cure with paucity of knowledge regarding its …

[PDF][PDF] UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO FACULTAD DE QUÍMICA

RGV BAENA - ru.dgb.unam.mx
Gracias a los cuidados perinatales ya la terapia antirretroviral en mujeres embarazadas
infectadas por el VIH, se ha reducido la transmisión vertical. Si bien están ausentes de la …