The properties of benzimidazole and its derivatives have been studied over more than one
hundred years. Benzimidazole derivatives are useful intermediates/subunits for the …

CXCR4 is a G-protein-coupled receptor involved in a number of physiological processes in
the hematopoietic and immune systems. The SDF-1/CXCR4 axis is significantly associated …

Entry of HIV into target cells is a complex, multi-stage process involving sequential
attachment and CD4 binding, coreceptor binding, and membrane fusion. HIV entry inhibitors …

Heterocyclic compounds are foundational in drug discovery, constituting the core structure of
approximately 80% of pharmaceuticals. Benzimidazole, in particular, emerges as a critical …

RECEPTORS Chemokines are small 70 amino acid long soluble proteins that chemoattract
a variety of mononuclear cell types to sites of inflammation or secondary lymphoid organs by …

The original bicyclam, JM1657 (JM standing for Johnson Matthey) was discovered as a
contaminant in a commercial preparation of monocyclams when evaluated for their anti-HIV …

Abstract The chemokine CXCL12 (SDF-1) and its cognate receptor CXCR4 are involved in a
large number of physiological processes including HIV-1 infectivity, inflammation …

The interaction between the chemokine receptor 4 (CXCR4) and stromal cell-derived factor-
1 (SDF-1, also known as CXCL12) is a natural regulatory process in the human body …

During the early preclinical phase, from hit identification and optimization to a lead
compound, several medicinal chemistry strategies can be used to improve potency and/or …

Background and Purpose The cyclopentapeptide FC 131 (cyclo (‐L‐A rg1‐L‐A rg2‐L‐2‐N
al3‐G ly4‐D‐T yr5‐)) is an antagonist at the CXC chemokine receptor CXCR 4, which plays …