4-Thiazolidinone-bearing hybrid molecules in anticancer drug design

P Roszczenko, S Holota, OK Szewczyk… - International Journal of …, 2022 - mdpi.com
Oncological diseases have currently reached an epidemic scale, especially in industrialized
countries. Such a situation has prompted complex studies in medicinal chemistry focused on …

The bioactivity of thiazolidin-4-ones: A short review of the most recent studies

D Mech, A Kurowska, N Trotsko - International Journal of Molecular …, 2021 - mdpi.com
Thiazolidin-4-ones is an important heterocyclic ring system of a pharmacophore and a
privileged scaffold in medicinal chemistry. This review is focused on the latest scientific …

Synthesis and antioxidant studies of 2, 4-dioxothiazolidine-5-acetic acid based organic salts: SC-XRD and DFT approach

SMA Mashhadi, MH Bhatti, E Jabeen, U Yunus… - ACS …, 2023 - ACS Publications
In the current study, two organic salts (1 and 2) are synthesized, and then crystalline
structures are characterized by FTIR, UV spectroscopy, and X-ray crystallographic studies …

A Review of the Recent Developments of Molecular Hybrids Targeting Tubulin Polymerization

O Ebenezer, M Shapi, JA Tuszynski - International Journal of Molecular …, 2022 - mdpi.com
Microtubules are cylindrical protein polymers formed from α β-tubulin heterodimers in the
cytoplasm of eukaryotic cells. Microtubule disturbance may cause cell cycle arrest in the …

Imidazopyridine, a promising scaffold with potential medicinal applications and structural activity relationship (SAR): recent advances

S Khatun, A Singh, GN Bader… - Journal of Biomolecular …, 2022 - Taylor & Francis
Imidazopyridine scaffold has gained tremendous importance over the past few decades.
Imidazopyridines have been expeditiously used for the rationale design and development of …

Anticancer Potential of the S‐Heterocyclic Ring Containing Drugs and its Bioactivation to Reactive Metabolites

S Maji, B Debnath, S Panda, T Manna… - Chemistry & …, 2024 - Wiley Online Library
Sulfur‐containing heterocyclic derivatives have been disclosed for binding with a wide
range of cancer‐specific protein targets. Various interesting derivatives of sulfur‐containing …

Synthesis, antibacterial and anthelmintic activity of novel 3-(3-pyridyl)-oxazolidinone-5-methyl ester derivatives

B Jin, J Chen, Z Sheng, M Sun, H Yang - Molecules, 2022 - mdpi.com
In this study, a series of 3-(3-pyridyl)-oxazolidone-5-methyl ester derivatives was
synthesized and characterized by 1H NMR, 13C NMR, and LC-MS. The conducted …

An alternative technique for cyclization synthesis, in vitro anti-esophageal cancer evaluation, and molecular docking of novel thiazolidin-4-one derivatives

AM Jassem, AM Dhumad, JK Salim, HA Jabir - Journal of Molecular …, 2023 - Elsevier
In this work, two novel series of thiazolidin-4-one derivatives (9a–e and 10a–e) constituting
ten compounds were synthesized under batch and ultrasound irradiation. It is found that the …

In vitro and in silico correlation of benzoxazole-based thiazolidinone hybrids derivatives: A promising acetylcholinesterase and butyrylcholinesterase inhibitors

M Ashraf, R Hussain, S Khan, W Rehman… - Journal of Molecular …, 2024 - Elsevier
Benzoxazole-based thiazolidinone hybrids derivatives (1–19) were afforded and further
subjected to in vitro acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) …

[PDF][PDF] Synthesis and antioxidant properties of novel 2-(2, 4-dioxothiazolidin-5-ylidene)-acetamides containing 1, 3, 4-thia/oxadiazole moieties

M Lelyukh, M Yu, V Flud, I Chaban… - … Res. Appl. Chem, 2022 - biointerfaceresearch.com
A series of novel 1, 3, 4-thia (oxa) diazole substituted 2-(2, 4-dioxothiazolidine-5-ylidene)-
acetamides 3a-c, 4 and 5a-k have been synthesized following the acylation reaction of 2 …